Article

Non-arteritic anterior ischaemic optic neuropathy in Malaysia: a 5 years review.

Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
International journal of ophthalmology 01/2011; 4(3):272-4. DOI:10.3980/j.issn.2222-3959.2011.03.12
Source: PubMed

ABSTRACT To evaluate the clinical presentations and visual outcomes of non-arteritic anterior ischaemic optic neuropathy (NAION).
A retrospective study was conducted involving 18 consecutive patients (20 eyes) with NAION attending Hospital Universiti Sains Malaysia from January 2005 until December 2009.
Most patients were Malay (94.4%), and followed by Chinese (5.6 %). The female-to-male ratio was 3.5:1. The age of patients ranged from 36 to 85 years (mean, 57.1 years). The main risk factors in systemic diseases were hypertension (55.5%), diabetes mellitus (44.4%), and ischaemic heart disease (11.1%). Most patients (77.8%) presented with acute loss of vision while gradual onset was in 22.3% of cases. Majority had visual acuity worse than 1/60 (80%). The most common fundoscopic findings were peripapillary splinter haemorrhage (90%), sectorial swollen optic disc (60%) and hyperemic disc (60%). During follow up, 20% of the patients showed stabilization in visual acuity, and 80% showed worsening of vision.
Majority of patients with NAION presented with acute poor vision involving middle-aged and elderly individuals. Hypertension and diabetes mellitus were among the main risk factors involved. NAION can lead to permanent visual loss despite treatment.

0 0
 · 
0 Bookmarks
 · 
21 Views
  • Article: Pathogenesis of nonarteritic anterior ischemic optic neuropathy.
    Anthony C Arnold
    [show abstract] [hide abstract]
    ABSTRACT: Based on histopathology, electron microscopic corrosion cast studies, optic nerve blood flow studies, and clinical data, the pathogenesis of idiopathic nonarteritic ischemic optic neuropathy includes the following features: (1) structurally crowded optic discs are predisposed; (2) laminar and retrolaminar regions are the most common locations for infarction; (3) there is flow impairment in the prelaminar optic disc during the acute phase; (4) lack of consistent choroidal flow impairment and the retrolaminar location of infarcts suggest vasculopathy within or distal to the paraoptic branches of the posterior choroidal arteries; (5) diabetes is the most consistently identified vasculopathic risk factor; (6) impaired autoregulation of the disc circulation by atherosclerosis, with a possible contribution from serotonin and endothelin-mediated vasospasm, may play a role; and (7) progression may be caused by secondary cell death after the initial ischemic insult or compression from cavernous degeneration and mechanical axonal distortion.
    Journal of Neuro-Ophthalmology 07/2003; 23(2):157-63. · 1.45 Impact Factor
  • Source
    Article: Nonarteritic ischemic optic neuropathy.
    Muh-Chiou Lin, Feng-Ming Hsu, Shwu-Jiuan Sheu
    [show abstract] [hide abstract]
    ABSTRACT: To describe the systemic and visual characteristics and prognosis in patients with nonarteritic ischemicoptic neuropathy (NAION) undergoing different treatments. Retrospective chart review was performed in Kaohsiung Veterans General Hospital patients from 1995-2005 with a clinical diagnosis of NAION, including nonarteritic anterior ischemic optic neuropathy and posterior ischemic optic neuropathy (PION). There were 14 PION patients out of a total of 103 cases. The average age at disease attack was 61 years old, and the ratio of males to females was 1.24:1. Comorbid systemic diseases and visual function were recorded at both initial presentation and the later follow-up period. The final results were recorded and compared by the different treatments they received in 4 groups. In all, NAION usually affected people > 50 years old, without any difference between sexes. Presenting visual acuity, age, and different treatment modes had no direct influence on the final visual outcome. The most significant associated factor was hypertension. NAION is a serious illness; the visual deficit persists even with aggressive treatment.
    Journal of the Chinese Medical Association 03/2007; 70(2):61-4. · 0.79 Impact Factor
  • Article: Anterior ischemic optic neuropathy in children: case reports and review of the literature.
    Abe M Chutorian, Jacqueline M S Winterkorn, Michael Geffner
    [show abstract] [hide abstract]
    ABSTRACT: Anterior ischemic optic neuropathy, infarction of the optic nerve head owing to inadequate perfusion through the posterior ciliary arteries, is a common cause of visual loss in adults but is rarely reported in children, in part because the diagnosis is overlooked. We report two cases of young children undergoing chronic peritoneal dialysis, who suffered bilateral visual loss from anterior ischemic optic neuropathy. Predisposing local anatomic and multiple systemic factors included a small optic nerve head with little cupping, possible intraocular hypertension, and systemic hypotension, hypovolemia, and anemia. The literature on anterior ischemic optic neuropathy is reviewed.
    Pediatric Neurology 06/2002; 26(5):358-64. · 1.52 Impact Factor

Show more

Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

18 consecutive patients
 
acute loss
 
acute poor vision
 
cases
 
clinical presentations
 
common fundoscopic findings
 
diabetes mellitus
 
elderly individuals
 
gradual onset
 
Hospital Universiti Sains Malaysia
 
hyperemic disc
 
ischaemic heart disease
 
main risk factors
 
NAION
 
non-arteritic anterior ischaemic optic neuropathy
 
patients
 
permanent visual loss
 
sectorial swollen optic disc
 
systemic diseases