Iron metabolism: interactions with normal and disordered erythropoiesis.

Department of Medicine and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095.
Cold Spring Harbor Perspectives in Medicine (Impact Factor: 7.56). 05/2012; 2(5):a011668. DOI: 10.1101/cshperspect.a011668
Source: PubMed

ABSTRACT Hemoglobinopathies and other disorders of erythroid cells are often associated with abnormal iron homeostasis. We review the molecular physiology of intracellular and systemic iron regulation, and the interactions between erythropoiesis and iron homeostasis. Finally, we discuss iron disorders that affect erythropoiesis as well as erythroid disorders that cause iron dysregulation.

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