Releasing Dye Encapsulated in Proteinaceous Microspheres on Conductive Fabrics by Electric Current

Department of Chemistry and Kanbar Laboratory for Nanomaterials Bar-Ilan University Center for Advanced Materials and Nanotechnology, Bar-Ilan University , Ramat-Gan 52900 (Israel).
ACS Applied Materials & Interfaces (Impact Factor: 6.72). 05/2012; 4(6). DOI: 10.1021/am3002132
Source: PubMed


The current paper reports on the relase properties of conductive fabrics coated with proteinaceous microspheres containing a dye. The release of the dye was achieved by passing an electric current through the fabric. The conductivity of the polyester fibers resulted from nanosilver (Ag NPs) coated on the surface of these fibers. Both types of coatings (nanosilver coating and the coating of the proteinaceous microspheres) were performed using high-intensity ultrasonic waves. Two different types of dyes, hydrophilic RBBR (Remazol Brilliant Blue R) and hydrophobic ORO (Oil Red O), were encapsulated inside the microspheres (attached to the surface of polyester) and then released by applying an electric current. The Proteinaceous Microsphere (PM)-coated conductive fabrics could be used in medicine for drug release. The encapsulated dye can be replaced with a drug that could be released from the surface of fabrics by applying a low voltage.

7 Reads
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: In the present study, the molecular and magnetic dual-targeted redox-responsive folic acid-cysteine-Fe3O4 microcapsules (FA-Cys-Fe3O4 MCs) have been synthesized via the sonochemical technique, and targeting molecule (folic acid) and Fe3O4 magnetic nanoparticles are introduced into the microcapsule shells successfully. The obtained FA-Cys-Fe3O4 MCs show excellent magnetic responsive ability by the oriented motion under an external magnetic field. The hydrophobic fluorescent dye (Coumarin 6) is successfully loaded into the FA-Cys-Fe3O4 MCs, demonstrating that it could be also easily realized to encapsulate hydrophobic drugs into the FA-Cys-Fe3O4 MCs when the drugs are dispersed into the oil phase before sonication. Cellular uptake demonstrates that FA-Cys-Fe3O4 MCs could target selectively the cells via folate-receptor-mediated endocytosis. Moreover, the FA-Cys-Fe3O4 MCs show their potential ability to be an attractive carrier for drug controlled release owing to the redox responsiveness of the disulfide in the microcapsule shells.
    ACS Applied Materials & Interfaces 12/2014; 7(5). DOI:10.1021/am5057097 · 6.72 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A facile sonochemical approach is designed to fabricate protein nanocapsules for hydrophilic drugs (HDs) and HD-loaded multifunctional bovine serum albumin (BSA) nanocapsules (MBNCs) have been prepared for the first time. The as-synthesized HD-loaded MBNCs have a satisfying size range and an excellent magnetic responsive ability. Moreover, high-dose hydrophilic drugs could be loaded into the MBNCs. As the carriers, HD-loaded MBNCs also show attractive redox-responsive controlled release ability for hydrophilic drugs and could be internalized selectively by the tumor cells through the folate-mediated endocytosis.
    ACS Applied Materials & Interfaces 08/2015; 7(34). DOI:10.1021/acsami.5b05558 · 6.72 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Multifunctional folic acid conjugated BSA@Fe3O4 microcapsules (FA-BSA@Fe3O4 MCs) have been prepared successfully based on the sonochemical method. The as-synthesized FA-BSA@Fe3O4 MCs have a suitable size range for biomedical applications, and a high loading capacity for water-insoluble drugs. Furthermore, FA-BSA@Fe3O4 MCs show excellent magnetic properties. Cytotoxicity tests indicate that FA-BSA@Fe3O4 MCs are non-toxic. Cellular uptake and flow cytometric assay illustrate together that FA-BSA@Fe3O4 MCs can target tumor cells selectively through molecular targeted endocytosis. As carriers for water-insoluble drugs, FA-BSA@Fe3O4 MCs are also proved to possess superior redox- and thermo- dual responsiveness for controlled drug release.
    Colloids and surfaces B: Biointerfaces 10/2015; 136. DOI:10.1016/j.colsurfb.2015.09.056 · 4.15 Impact Factor
Show more