Article

T-regulatory cells: key players in tumor immune escape and angiogenesis.

Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Cancer Research (impact factor: 7.86). 05/2012; 72(9):2162-71. DOI:10.1158/0008-5472.CAN-11-3687 pp.2162-71
Source: PubMed

ABSTRACT T-regulatory cells (Tregs) are found infiltrating tumors in a vast array of tumor types, and tumor-infiltrating Tregs are often associated with a poor clinical outcome. Tregs are potent immunosuppressive cells of the immune system that promote progression of cancer through their ability to limit antitumor immunity and promote angiogenesis. Here, we discuss the ways in which Tregs suppress the antitumor immune response and elaborate on our recent discovery that Tregs make significant direct contributions to tumor angiogenesis. Further, we highlight several current therapies aimed at eliminating Tregs in cancer patients. Given the multifaceted role of Tregs in cancer, a greater understanding of their functions will ultimately strengthen future therapies.

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Keywords

antitumor immune response
 
cancer patients
 
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limit antitumor immunity
 
multifaceted role
 
poor clinical outcome
 
promote progression
 
recent discovery
 
significant direct contributions
 
T-regulatory cells
 
Tregs
 
tumor types
 
tumor-infiltrating Tregs
 
vast array