Article

Bio-inspired synthesis and biological evaluation of a colchicine-related compound library.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
Bioorganic & medicinal chemistry letters (impact factor: 2.65). 04/2012; 22(11):3776-80. DOI:10.1016/j.bmcl.2012.04.007 pp.3776-80
Source: PubMed

ABSTRACT A bio-inspired investigation of the reactions of substrates of type 1 with VOF(3) and PIFA [phenyliodine(III) bis(trifluoroacetate)] led to a collection of colchicine-like compounds 2-5 and related systems. Biological evaluation revealed that some of the synthesized products had significant cytotoxic properties against the colon cancer cell line HT-29.

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Keywords

colchicine-like compounds 2-5
 
colon cancer cell line HT-29
 
reactions
 
synthesized products
 

K C Nicolaou