Low-level exposure to ambient particulate matter is associated with systemic inflammation in ischemic heart disease patients

Department of Environmental Health, National Institute for Health and Welfare, Kuopio, Finland.
Environmental Research (Impact Factor: 3.95). 04/2012; 116:44-51. DOI: 10.1016/j.envres.2012.04.004
Source: PubMed

ABSTRACT Short-term exposure to ambient air pollution is associated with increased cardiovascular mortality and morbidity. This adverse health effect is suggested to be mediated by inflammatory processes. The purpose of this study was to determine if low levels of particulate matter, typical for smaller cities, are associated with acute systemic inflammation. Fifty-two elderly individuals with ischemic heart disease were followed for six months with biweekly clinical visits in the city of Kotka, Finland. Blood samples were collected for the determination of inflammatory markers interleukin (IL)-1Β, IL-6, IL-8, IL-12, interferon (IFN)γ, C-reactive protein (CRP), fibrinogen, myeloperoxidase and white blood cell count. Particle number concentration and fine particle (particles with aerodynamic diameters <2.5μm (PM 2.5)) as well as thoracic particle (particles with aerodynamic diameters <10μm (PM 10)) mass concentration were measured daily at a fixed outdoor measurement site. Light-absorbance of PM 2.5 filter samples, an indicator of combustion derived particles, was measured with a smoke-stain reflectometer. In addition, personal exposure to PM 2.5 was measured with portable photometers. During the study period, wildfires in Eastern Europe led to a 12-day air pollution episode, which was excluded from the main analyses. Average ambient PM 2.5 concentration was 8.7μg/m 3. Of the studied pollutants, PM 2.5 and absorbance were most strongly associated with increased levels of inflammatory markers; most notably with C-reactive protein and IL-12 within a few days of exposure. There was also some evidence of an effect of particulate air pollution on fibrinogen and myeloperoxidase. The concentration of IL-12 was considerably (227%) higher during than before the forest fire episode. These findings show that even low levels of particulate air pollution from urban sources are associated with acute systemic inflammation. Also particles from wildfires may exhibit pro-inflammatory effects.

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    • "For the two studies that investigated birth weight, results were inconsistent (Holstius et al., 2012; Prass et al., 2012). All three cohort studies reported significant adverse associations between wildfires and health: systemic inflammation (Huttunen et al., 2012), bone marrow content (Tan et al., 2000), and physical strength and overall health (Frankenberg et al., 2005). Diarrhea and diabetes were mentioned as health outcomes of interest in multiple studies (Aditama 2000; Jalaludin et al., 2000; Lee et al., 2009; Viswanathan et al., 2006), but only two reported the results (Lee et al., 2009; Viswanathan et al., 2006). "
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    Environmental Research 01/2015; 136. DOI:10.1016/j.envres.2014.10.015 · 3.95 Impact Factor
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    • "Recent air quality studies indicate a rising worldwide concern due to the significant contribution of biomass combustion to ambient air pollution (Glasius et al., 2008; Gustafson et al., 2008; Hell en et al., 2008) and underline the importance of using efficient wood combustion technologies to improve the air quality in residential areas (Bari et al., 2010, 2011; Gonçalves et al., 2012; Huttunen et al., 2012; Kaivosoja et al., 2012; Meyer, 2012; Piazzalunga et al., 2013). While the above presented studies addressed quantitative estimate of the contribution from the residential heating to the ambient air quality, very few have aimed at the investigation of the contribution of the products of fuel combustion to the indoor air quality. "
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    Reviews on environmental health 09/2012; DOI:10.1515/reveh-2012-0012
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