Article

[Effects of bacterial lipopolysaccharide on serum IL-4, serum IL-8 and pulmonary VEGF expression in mice with asthma].

Department of Pediatrics, Zhengzhou University, Zhengzhou, China.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 04/2012; 14(4):297-300. pp.297-300
Source: PubMed

ABSTRACT To study the regulatory role of bacterial lipopolysaccharide (LPS ) in the development of bronchial asthma by examining the effects of LPS on serum IL-4, serum IL-8 and pulmonary vascular endothelial growth factor (VEGF) expression in mice with asthma.
Twenty-seven BALB/c mice were randomly assigned into control, asthma and LPS-treated asthma groups (n=9 each). Serum IL-4 and IL-8 concentrations were measured using ELISA. VEGF expression in lung tissues was examined using the immunohistochemical method.
Serum IL-4 and IL-8 concentrations in the asthma group were significantly higher than in the control group (P<0.05). LPS treatment significantly decreased serum IL-4 and IL-8 concentrations compared with the asthma group (P<0.05), although levels were significantly higher than in the control group (P<0.05). Airway VEGF expression in the asthma group was significantly higher than in the control group (P<0.05). LPS treatment significantly decreased airway VEGF expression compared with the asthma group (P<0.05), although concentrations remained higher than in the control group (P<0.05).
LPS can decrease serum IL-4, serum IL-8 and pulmonary VEGF expression in mice with asthma, and thus can possibly reduce both airway inflammation and airway vascular remodeling.

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Keywords

airway inflammation
 
airway vascular
 
airway VEGF expression
 
asthma group
 
bacterial lipopolysaccharide
 
BALB/c mice
 
bronchial asthma
 
control group
 
immunohistochemical method
 
LPS
 
LPS-treated asthma groups
 
lung tissues
 
mice
 
P<0.05). Airway VEGF expression
 
pulmonary vascular endothelial growth factor
 
pulmonary VEGF expression
 
regulatory role
 
Serum IL-4
 
serum IL-8
 
VEGF expression