Article

Infectious complications associated with the use of acellular dermal matrix in implant-based bilateral breast reconstruction.

Division of Plastic Surgery, University of Kentucky College of Medicine, Lexington, KY, USA.
Annals of plastic surgery (impact factor: 1.29). 05/2012; 68(5):432-4. DOI:10.1097/SAP.0b013e31823b6ac6 pp.432-4
Source: PubMed

ABSTRACT The use of acellular dermal matrix (ADM) has become a routine practice in implant-based breast reconstruction. Bilateral mastectomy is becoming more popular in cases of unilateral breast cancer. ADM has been associated with an increased incidence of complications.
We identified cases of bilateral implant-based breast reconstruction over a 5-year period. Data collection included medical comorbities, details of operative management, and details of postoperative cancer treatment.
On univariate analysis, the use of ADM (31% vs. 7%, P = 0.018), smoking (37% vs. 13%, P = 0.045), and open wound (55% vs. 13%, P = 0.006) were significantly associated with increased risk of infection. Multivariate analysis revealed open wound as the strongest predictor of infection.
The use of ADM is associated with an increased risk of infection in bilateral implant-based breast reconstruction. However, it does not appear to be an independent risk factor by itself.

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Keywords

5-year period
 
acellular dermal matrix
 
ADM
 
bilateral implant-based breast reconstruction
 
Bilateral mastectomy
 
cases
 
Data collection
 
implant-based breast reconstruction
 
increased incidence
 
increased risk
 
independent risk factor
 
medical comorbities
 
Multivariate analysis
 
operative management
 
postoperative cancer treatment
 
routine practice
 
strongest predictor
 
univariate analysis