Article

Reverse genetics of influenza viruses.

Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Methods in molecular biology (Clifton, N.J.) 01/2012; 865:193-206. DOI:10.1007/978-1-61779-621-0_12 pp.193-206
Source: PubMed

ABSTRACT The ability to modify influenza viruses at will has revolutionized influenza research. Reverse genetics has been used to generate mutant or reassortant influenza viruses to assess their replication, virulence, pathogenicity, host range, and transmissibility. Moreover, this technology is now being used to generate approved influenza virus vaccines and develop novel vaccines to combat seasonal and (future) pandemic influenza viruses. Several variations of the original system have been established, all of which are considerably robust and efficient.

0 0
 · 
0 Bookmarks
 · 
47 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

host range
 
influenza virus vaccines
 
influenza viruses
 
mutant
 
novel vaccines
 
pathogenicity
 
reassortant influenza viruses
 
replication
 

Gabriele Neumann