Preoperative metastatic status, level of thrombus and body mass index predict overall survival in patients undergoing nephrectomy and inferior vena cava thrombectomy.

Departments of Genitourinary Oncology Biostatistics, Moffitt Cancer Center, Tampa, FL, USA.
BJU International (Impact Factor: 3.05). 04/2012; DOI: 10.1111/j.1464-410X.2012.11155.x
Source: PubMed

ABSTRACT Study Type - Prognosis (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Little is known about the prognostic impact of body mass index (BMI) and obesity on patients with locally advanced kidney cancer. Previous studies suggest that clinical/pathological stage, the proximal extent of the tumour thrombus, direct vascular wall invasion, and preoperative performance status may all constitute important prognostic factors within this patient population. The present study shows that a patient's metastatic status, higher level of tumour thrombus, and lower BMI all constitute adverse predictors of overall survival in patients who have RCC with inferior vena cava tumour thrombus. OBJECTIVE: •  To determine which clinical variables, including body mass index (BMI), predict overall survival (OS) after nephrectomy with inferior vena cava (IVC) thrombectomy for renal cell carcinoma (RCC) with tumour thrombus. PATIENTS AND METHODS: •  After institutional review board approval, a retrospective analysis of all patients (N= 100) undergoing nephrectomy and IVC thrombectomy for RCC from 1989 to 2010 were reviewed. One patient was excluded owing to missing clinical information leaving 99 patients in the study cohort. •  Patients were placed into one of two subgroups, based on their preoperative BMI (BMI ≤30 kg/m(2) or BMI >30 kg/m(2) ). •  Complications, blood loss, level of tumour thrombus, side of tumour and follow-up data were tabulated. RESULTS: •  Fifty-six patients had a BMI ≤30 kg/m(2) and 43 patients had a BMI >30 kg/m(2) . Intraoperative complications occurred in 14% of those with BMI >30 kg/m(2) and 5.4% of those with a BMI ≤30 kg/m(2) (P= 0.171). •  On multivariate analysis, a higher thrombus level (III/IV vs I/II) and the presence of metastatic disease at time of diagnosis was associated with a worse OS (P= 0.041 and P < 0.001, respectively). •  The subgroup with a higher preoperative BMI had a significantly better OS (hazard ratio 0.42; 95% confidence interval 0.22-0.80, P= 0.009). •  Similarly, our Kaplan-Meier survival analysis showed an improved OS in the patient cohort with a BMI >30 kg/m(2) (P= 0.016). CONCLUSION: •  Important predictors of outcome in patients undergoing nephrectomy with IVC thrombectomy for RCC with tumour thrombus include preoperative BMI, level of IVC tumour thrombus, and metastatic status at time of surgery.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Renal cell carcinoma (RCC) extension into the renal vein or the inferior vena cava occurs in 4 %-10 % of all kidney cancer cases. This entity shows a wide range of different clinical and surgical scenarios, making natural history and oncological outcomes variable and poorly characterized. Infrequency and variability make it necessary to share the experience from different institutions to properly analyze surgical outcomes in this setting. The International Renal Cell Carcinoma-Venous Tumor Thrombus Consortium was created to answer the questions generated by competing results from different retrospective studies in RCC with venous extension on current controversial topics. The aim of this article is to summarize the experience gained from the analysis of the world's largest cohort of patients in this unique setting to date.
    Current Urology Reports 05/2014; 15(5):404.
  • [Show abstract] [Hide abstract]
    ABSTRACT: To identify the prognostic impact of venous tumor thrombus in locally-advanced renal cell carcinomas (RCC) To further differentiate the clinical course of patients with VTT despite similar clinicopathological characteristics PATIENTS AND METHODS: Determination of the VTT consistency (solid vs. friable) and the correlation with clinical and pathological parameters A retrospective cohort of 200 RCC patients nephrectomized between 1994 and 2011 RESULTS: 65% with a solid VTT, 35% with friable VTT which demonstrates a significant decrease in cell-cell adhesion molecules and connective tissue Correlation of a friable VTT with advanced pT-stage, higher VTT level, papillary RCC subtype, and a lower age Significantly shorter median overall survival of patients with a friable, than in patients with a solid VTT (29 vs. 89 months), but failure of VTT consistency as an independent predictor of patients' survival in the multivariate Cox analysis VTT consistency as an independent significant predictor of overall survival in patients without evidence of distant and nodal metastases (n=119) CONCLUSION: VTT consistency caused by the tumor and not different surgical handling A friable VTT as an important adverse prognostic predictor of overall survival in patients with non-metastatic RCC.
    BJU International 06/2013; · 3.05 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Inferior vena cava tumor thrombectomy requires experienced surgical teams due to complex hemodynamic considerations, often utilizing vascular bypass techniques that introduce additional risk. Control of the IVC within the pericardium obviates the need for cardiopulmonary bypass (CPB). We reviewed our experience with intrapericardial control during IVC tumor thrombectomy to evaluate perioperative outcomes and determine factors associated with overall survival. We completed a retrospective review of 87 patients who underwent nephrectomy with IVC tumor thrombectomy using intrapericardial IVC control from 1978-2012. This technique was performed in all cases of intrahepatic (n=43) and supradiaphragmatic (n=35) thrombi, and select cases of intra-atrial (n=9) thrombi. Patient demographics, operative variables, and post-operative outcomes were examined. Multivariate regression analysis was used to determine associations between clinical variables and overall survival. Perioperative mortality (30-day) was 9.2% and incidence of high-grade complications was 19.5%. Median survival was 3.1 years and 2.5 years for pT3bN0 and pT3cN0 patients, respectively. Extended regional lymphadenectomy, performed in all cases revealed nodal metastasis in 36% of patients. On multivariate analysis, ECOG >2 and pT3c stage were associated with worse survival. Histologic grade, perinephric fat invasion and presence of lymph node involvement were not associated with worse survival. Intrapericardial control of the IVC allows a single surgical team to safely perform tumor thrombectomy for intrahepatic and supradiaphragmatic thrombi, eliminating risk and morbidity related to CPB. Though supradiaphragmatic extent and ECOG >2 are associated with worse survival, complete resection with lymphadenectomy can allow long-term survival in patients with locally advanced disease.
    The Journal of urology 04/2014; · 3.75 Impact Factor

Full-text (2 Sources)

Available from
Oct 3, 2014