Article

Mechanisms of gene regulation by fatty acids.

Nutrition, Metabolism and Genomics Group, Wageningen University, the Netherlands.
Advances in nutrition (Bethesda, Md.) 01/2012; 3(2):127-34. DOI:10.3945/an.111.001602 pp.127-34
Source: PubMed

ABSTRACT Consumption of specific dietary fatty acids has been shown to influence risk and progression of several chronic diseases, such as cardiovascular disease, obesity, cancer, and arthritis. In recent years, insights into the mechanisms underlying the biological effects of fatty acids have improved considerably and have provided the foundation for the emerging concept of fatty acid sensing, which can be interpreted as the property of fatty acids to influence biological processes by serving as signaling molecules. An important mechanism of fatty acid sensing is via stimulation or inhibition of DNA transcription. Here, we focus on fatty acid sensing via regulation of gene transcription and address the role of peroxisome proliferator-activated receptors, sterol regulatory element binding protein 1, Toll-like receptor 4, G protein-coupled receptors, and other putative mediators.

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Keywords

biological effects
 
emerging concept
 
fatty acid
 
fatty acids
 
G protein-coupled receptors
 
gene transcription
 
influence biological processes
 
insights
 
obesity
 
peroxisome proliferator-activated receptors
 
progression
 
recent years
 
signaling molecules
 
specific dietary fatty acids
 
sterol regulatory element binding protein 1
 
Toll-like receptor 4