Conference Proceeding

A simulator for the electro-chemical dynamics of the human cardiac cell

10/2003; 3:2750 - 2753 Vol.3. DOI:10.1109/IEMBS.2003.1280486 In proceeding of: Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE, Volume: 3
Source: IEEE Xplore

ABSTRACT A simulator of the ionic dynamics in the human cardiomyocyte (E-C coupling process) is developed in this work using Matlab® v 6.5. It contains three different mathematical models, namely the models by Tang and Othmer, Luo and Rudy and Roche et al. Its user-friendly interface allows the comparison between the three models, the modification of the model parameters in correspondence with different cellular elements, and hence the testing of the sensibility of the E-C process to drugs and inhibitors. The simulator also features a graphics builder for the visualization of the results, and facilities to export data to other formats such as Excel®, or import experimental data from files. The simulator is compiled in a binary executable program and therefore is fully transportable.

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