Conference Paper

# Behavioural Simulation and Synthesis of Biological Neuron Systems using VHDL

Sch. of Electron. & Comput. Sci., Univ. of Southampton, Southampton

DOI: 10.1109/BMAS.2008.4751231 Conference: Behavioral Modeling and Simulation Workshop, 2008. BMAS 2008. IEEE International Source: IEEE Xplore

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Peter R. Wilson, Oct 06, 2014 Available from: Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

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- The Journal of Physiology 09/1952; 117(4):500-44. DOI:10.1016/S0092-8240(05)80004-7 · 5.04 Impact Factor
- Comprehensive Physiology, 12/2010; , ISBN: 9780470650714
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**ABSTRACT:**Mathematical expressions are obtained for the response function corresponding to an instantaneous pulse of current injected to a single dendritic branch in a branched dendritic neuron model. The theoretical model assumes passive membrane properties and the equivalent cylinder constraint on branch diameters. The response function when used in a convolution formula enables one to compute the voltage transient at any specified point in the dendritic tree for an arbitrary current injection at a given input location. A particular numerical example, for a brief current injection at a branch terminal, illustrates the attenuation and delay characteristics of the depolarization peak as it spreads throughout the neuron model. In contrast to the severe attenuation of voltage transients from branch input sites to the soma, the fraction of total input charge actually delivered to the soma and other trees is calculated to be about one-half. This fraction is independent of the input time course. Other numerical examples, which compare a branch terminal input site with a soma input site, demonstrate that, for a given transient current injection, the peak depolarization is not proportional to the input resistance at the injection site and, for a given synaptic conductance transient, the effective synaptic driving potential can be significantly reduced, resulting in less synaptic current flow and charge, for a branch input site. Also, for the synaptic case, the two inputs are compared on the basis of the excitatory post-synaptic potential (EPSP) seen at the soma and the total charge delivered to the soma.Biophysical Journal 11/1974; 14(10):759-90. DOI:10.1016/S0006-3495(74)85948-5 · 3.97 Impact Factor