Conference Paper

Progress in self-stabilizing capsules for imaging of the large intestine

DOI: 10.1109/ICECS.2010.5724496 Conference: Electronics, Circuits, and Systems (ICECS), 2010 17th IEEE International Conference on
Source: IEEE Xplore


This work reports on the progress and development advances in the design of self-stabilizing capsules for imaging the lower part of the gastro-intestinal tract, namely the large intestine (the colon). Macro-level design is reviewed, and the new miniaturized design and its components are described. Preliminary performance results are discussed.

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    • "This stabilizing component was a thermally-treated, woven, biodegradable, liquid-permeable, flexible polyglactin 910 mesh (Vicryl, Ethicon Inc., Somerville, NJ) filled with superabsorbent polymer granules (Favor PAC, Evonik Industries, Stockhausen, Germany) [26]. Initially, the mesh was thermally processed to age it for a biodegradability of 2–3 days and to obtain oval shape (side length cm, radius cm) followed by cutting a slit (5 mm) through which the polymer ( ml) was inserted into the oval-shaped mesh. "
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    ABSTRACT: Video capsule endoscopy (VCE) is a noninvasive method for examining the gastrointestinal tract which has been successful in small intestine studies. Recently, VCE has been attempted in the colon. However, the capsule often tumbles in the wider colonic lumen, resulting in missed regions. Self-stabilizing VCE is a novel method to visualize the colon without tumbling. The aim of the present study was to comparatively quantify the effect of stabilization of a commercially available nonmodified capsule endoscope (CE) MiroCam and its modified self-stabilizing version in acute canine experiments. Two customized MiroCam CEs were reduced in volume at the nonimaging back-end to allow the attachment of a self-expanding, biocompatible stabilizing device. Four mongrel dogs underwent laparotomy and exteriorization of a 15-cm segment of the proximal descending colon. A single CE, either self-stabilizing or nonmodified was inserted through an incision into the lumen of the colon followed by pharmacologically induced colonic peristalsis. The inserted capsule was propelled distally through the colon and expelled naturally through the anus. Novel signal processing method was developed to quantify the video stabilization based on camera tracking a predetermined target point (locale). The average locale trajectory, the average radius movement of the locale, and the maximum rate of change of the locale for sequential images were significantly lower for the stabilized capsules compared to the nonstabilized ones . The feasibility of self-stabilized capsule endoscopy has been demonstrated in acute canine experiments.
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    ABSTRACT: Currently, the major problem of all existing commercial capsule devices is the lack of control of movement. In the future, with an interface application, the clinician will be able to stop and direct the device into points of interest for detailed inspection/diagnosis, and therapy delivery. This editorial presents current commercially available new designs, European projects and drug delivery capsules, and gives an overview of the progress required and progress that will be achieved -according to the opinion of the authors- in the next 5 year leading to 2020.
    World Journal of Gastroenterology 05/2015; 21(17):5119-5130. DOI:10.3748/wjg.v21.i17.5119 · 2.37 Impact Factor