Article

Metrics on Multilabeled Trees: Interrelationships and Diameter Bounds

IEEE/ACM Transactions on Computational Biology and Bioinformatics (impact factor: 1.54). 09/2011; DOI:10.1109/TCBB.2010.122 pp.1029 - 1040
Source: IEEE Xplore

ABSTRACT Multilabeled trees or MUL-trees, for short, are trees whose leaves are labeled by elements of some nonempty finite set X such that more than one leaf may be labeled by the same element of X. This class of trees includes phylogenetic trees and tree shapes. MUL-trees arise naturally in, for example, biogeography and gene evolution studies and also in the area of phylogenetic network reconstruction. In this paper, we introduce novel metrics which may be used to compare MUL-trees, most of which generalize well-known metrics on phylogenetic trees and tree shapes. These metrics can be used, for example, to better understand the space of MUL-trees or to help visualize collections of MUL-trees. In addition, we describe some relationships between the MUL-tree metrics that we present and also give some novel diameter bounds for these metrics. We conclude by briefly discussing some open problems as well as pointing out how MUL-tree metrics may be used to define metrics on the space of phylogenetic networks.

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Keywords

define metrics
 
gene evolution studies
 
generalize well-known metrics
 
metrics
 
MUL-tree metrics
 
MUL-trees
 
Multilabeled trees
 
nonempty finite
 
novel diameter bounds
 
novel metrics
 
phylogenetic network reconstruction
 
phylogenetic networks
 
phylogenetic trees
 
relationships
 
tree shapes
 
trees
 
visualize collections
 

K. T. Huber