Article

A Simulation Tool to Study High-Frequency Chest Compression Energy Transfer Mechanisms and Waveforms for Pulmonary Disease Applications

Med. Sch., Dept. of Pediatrics, Univ. of Minnesota, Minneapolis, MN, USA
IEEE Transactions on Biomedical Engineering (impact factor: 2.28). 08/2010; DOI:10.1109/TBME.2010.2041453
Source: IEEE Xplore

ABSTRACT High-frequency chest compression (HFCC) can be used as a therapeutic intervention to assist in the transport and clearance of mucus and enhance water secretion for cystic fibrosis patients. An HFCC pump-vest and half chest-lung simulation, with 23 lung generations, has been developed using inertance, compliance, viscous friction relationships, and Newton's second law. The simulation has proven to be useful in studying the effects of parameter variations and nonlinear effects on HFCC system performance and pulmonary system response. The simulation also reveals HFCC waveform structure and intensity changes in various segments of the pulmonary system. The HFCC system simulation results agree with measurements, indicating that the HFCC energy transport mechanism involves a mechanically induced pulsation or vibration waveform with average velocities in the lung that are dependent upon small air displacements over large areas associated with the vest-chest interface. In combination with information from lung physiology, autopsies and a variety of other lung modeling efforts, the results of the simulation can reveal a number of therapeutic implications.

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Keywords

23 lung generations
 
chest-lung simulation
 
cystic fibrosis patients
 
HFCC energy transport mechanism
 
HFCC pump-vest
 
HFCC system performance
 
HFCC system simulation results
 
HFCC waveform structure
 
High-frequency chest compression
 
lung modeling efforts
 
lung physiology
 
mechanically induced pulsation
 
Newton's second law
 
small air displacements
 
therapeutic implications
 
therapeutic intervention
 
various segments
 
vest-chest interface
 
viscous friction relationships
 
water secretion
 

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