Conference Proceeding

A cell impedance sensor based on a silicon cochlea

12/2009; DOI:10.1109/BIOCAS.2009.5372071 pp.117 - 120 In proceeding of: Biomedical Circuits and Systems Conference, 2009. BioCAS 2009. IEEE
Source: IEEE Xplore

ABSTRACT In this paper, we present the design of an integrated CMOS sensor for cell impedance measurement. To achieve simultaneous measurements over a wide frequency range, the impedance sensor has been developed using silicon cochleae as both the input stimulus generator and the output frequency analyzer. This solution, inspired by the accuracy and efficiency of biological systems, has several advantages. The silicon cochlea is able to make measurements over a very wide frequency range (from Hz to MHz) with variable resolution. Power consumption of the sensor is below 30 ¿W due to the biasing regime used in the silicon cochleae. Furthermore, the implementation of the sensor is fully autonomous requiring no reference clocks or signal generators, facilitating integration into larger cell analysis systems.

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Keywords

biological systems
 
cell impedance measurement
 
input stimulus generator
 
integrated CMOS sensor
 
larger cell analysis systems
 
measurements
 
MHz
 
output frequency analyzer
 
Power consumption
 
signal generators
 
silicon cochlea
 
silicon cochleae
 
simultaneous measurements
 
variable resolution
 
wide frequency range