Article

Autonomic cardiovascular modulation

Univ. of Milan, Milan, Italy
IEEE Engineering in Medicine and Biology Magazine (impact factor: 2.06). 01/2010; DOI:10.1109/MEMB.2009.934620 pp.79 - 85
Source: IEEE Xplore

ABSTRACT The aim of the study was twofold: first, to validate symbolic analysis as a tool capable of assessing autonomic cardiovascular regulation in rats and, second, to investigate neural cardiovascular regulation during the progression of ischemic induced chronic heart failure (CHF) in two groups of rats, a control group and a group treated with chronic administration of the mineralocorticoid receptor antagonist SP, a drug playing a protective role over cardiovascular regulation.

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    Article: Linear and nonlinear analysis of heart rate variability in coronary disease.
    Victor Ribeiro Neves, Anielle Cristhine Medeiros Takahashi, Michele Daniela Borges do Santos-Hiss, Antti Mikael Kiviniemi, Mikko Paavo Tulppo, Silvia Cristina Garcia de Moura, Marlus Karsten, Audrey Borghi-Silva, Alberto Porta, Nicola Montano, Aparecida Maria Catai
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    ABSTRACT: Coronary artery disease (CAD) and acute myocardial infarction (AMI) are associated with a reduction of heart rate variability (HRV). The aim of this study was to compare the HRV of CAD patients with and without AMI (CAD-AMI) with health-matched controls by linear (spectral analysis) and nonlinear [Shannon entropy (SE), conditional entropy (CE) and symbolic analysis (SA)] analysis. Fifty-eight men were divided into three groups: healthy (n = 19, 57 ± 4 years), CAD (n = 20, 56 ± 10 years) and CAD-AMI (n = 19, 54 ± 12 years). The RR intervals were recorded at rest in the supine position for 10 min with an HR monitor (Polar(®)S810i). A series of 250 beats was selected to analyze variance, spectral analysis, SE, CE [complexity index (CI), normalized CI (NCI)] and SA (0V, 1V, 2LV and 2ULV patterns), as well as 0V (no significant variation) and 2ULV (two significant unlike variations), which reflect sympathetic and vagal modulation, respectively. One-way ANOVA (or the Kruskal-Wallis test when appropriate) and Pearson correlation were used. The CAD group had higher body mass index and weight than the CAD-AMI group, but no differences were found between the healthy and AMI groups. There were no differences between the groups regarding linear and nonlinear analysis. The 0V and 2ULV patterns were significantly correlated with the SE, CI and NCI of the three groups. There was no difference between the groups regarding cardiac autonomic modulation by linear and nonlinear methods, which may be due to beta-blocker use, coronary angioplasty and the exercise capacity of healthy subjects.
    Clinical Autonomic Research 04/2012; 22(4):175-83. · 1.30 Impact Factor
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Keywords

autonomic cardiovascular regulation
 
cardiovascular regulation
 
chronic administration
 
ischemic induced chronic heart failure
 
mineralocorticoid receptor antagonist SP
 
neural cardiovascular regulation
 
protective role
 
tool capable
 
validate symbolic analysis