Blood-brain barrier Recent developments and clinical correlations

Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Neurology (Impact Factor: 8.29). 04/2012; 78(16):1268-76. DOI: 10.1212/WNL.0b013e318250d8bc
Source: PubMed
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    • "Na/H exchange in the blood–brain barrier is prominently sensitive to amiloride and MIA (Murphy and Johanson, 1990; Sipos et al., 2005; Pedersen et al., 2006) and a high binding capacity of MIA has been demonstrated in cerebral microvessels (Kalaria et al., 1998). The endothelial isoforms of Na/H exchangers are located on the luminal side of endothelial cells (Crone, 1986; Goldstein et al., 1986; Redzic, 2011; Benarroch, 2012), and therefore , they are easily accessible to systemically applied Na/H exchange inhibitors, regardless of the drug permeability across the blood–brain barrier. Amiloride is poorly permeable in the blood– brain barrier (Sipos and Brem, 2000; Fisher, 2002; Liu et al., 2010), and notably, our present study shows that amiloride is as effective as MIA in abolishing post-asphyxia seizures. "
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