Article

Influence of skin type, race, sex, and anatomic location on epidermal barrier function.

Department of Dermatology and Venereology, Tokuda Hospital-Sofia, 51B Nikola Vaptsarov Blvd, 1407 Sofia, Bulgaria.
Clinics in dermatology (impact factor: 3.11). 05/2012; 30(3):269-73. DOI:10.1016/j.clindermatol.2011.08.013 pp.269-73
Source: PubMed

ABSTRACT The intact skin represents a barrier to the uncontrolled loss of water, proteins, and plasma components from the organism. Owing to its complex structure, the epidermal barrier with its major layer, the stratum corneum, is the rate-limiting unit for the penetration of exogenous substances through the skin. The epidermal barrier is not a static structure. The status of different functions of the epidermis can be monitored by assessing specific biophysical parameters such as transepidermal water loss, stratum corneum hydration, and skin surface pH. Variables originating from the individual as well as exogenous factors have an important influence on the epidermal barrier parameters.

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Keywords

complex structure
 
exogenous factors
 
exogenous substances
 
intact skin
 
rate-limiting unit
 
specific biophysical parameters
 
static structure
 
stratum corneum
 
stratum corneum hydration
 
transepidermal water loss
 
uncontrolled loss
 
Variables originating