Incidence of Restless Legs Syndrome and Its Correlates

Southern Arizona VA HealthCare System, 3601 S 6th Ave, Tucson, Arizona 85723, USA.
Journal of clinical sleep medicine: JCSM: official publication of the American Academy of Sleep Medicine (Impact Factor: 3.05). 04/2012; 8(2):119-24. DOI: 10.5664/jcsm.1756
Source: PubMed


Restless legs syndrome (RLS) is a common sensorimotor disorder whose incidence is not known. The aim of the study was to determine the incidence and correlates of RLS in a population-based sample.
We obtained data from the Tucson Cohort of the Sleep Heart Health Study, a prospective multicenter study. This cohort included 535 participants aged ≥ 40 years, who answered questions regarding RLS on the 2002 and 2006 sleep surveys. For this study, RLS was defined as the presence of all 4 International RLS Study Group criteria, with symptoms occurring ≥ 5 days/month and associated with at least moderate distress.
Mean age of the predominantly Caucasian (90.8%) participants on the 2002 survey was 59.8 ± 9.7 years; 52.2% were women. RLS prevalence was 4.1% in 2002 and 7.7% in 2006. The yearly incidence of RLS was 1.7% (6.6% over 4 years). Multivariate analyses demonstrated that estrogen use (OR = 2.5, 95% CI: 1.17-5.10) and self-reported obstructive lung disease (OR = 2.8, 95% CI: 1.37-5.83) were independent risk factors predicting incident RLS. Incident RLS was associated with higher prevalence of insomnia (26.5% vs. 7.6%, p = 0.001), increased sleepiness (38.2% vs. 22%, p = 0.036); and higher sleeping pill use in 2006 (23.5% vs. 9.7%, p = 0.019).
The incidence of RLS in this population sample was 1.7% per year. Use of estrogen and history of obstructive lung disease were associated with a significantly higher incidence of RLS. RLS, in turn, was associated with insomnia and increased sleepiness.

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    • "Hence, patients with leg discomforts visit spine clinics for identifying their spine problems. The restless legs syndrome (RLS) is also a common disorder affecting up to 5% to 15% of the general population, in which the incidence increases with age5,11,33,44), and includes paresthesia in the legs, that occurs at rest, and worsens in the evening, but improved by movements. Hemmer et al.21) reported RLS associated with myelopathy in one patient with a Borrelia induced myelitis and Zwartbol et al.51) presented patients with an acute acceleration of RLS due to cervical cord ischemia. "
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    ABSTRACT: The restless legs syndrome (RLS) is a common disorder affecting up to 5% to 15% of the general population, in which the incidence increases with age, and includes paresthesia in the legs. The purpose of this study is to investigate the incidence of RLS in spine center and to review clinical manifestations of this syndrome and its current treatments. Over a period of a year, retrospective medical record review and lumbar magnetic resonance images were performed on 32 patients with RLS in spine clinic who were diagnosed by National Institutes of Health criteria. Affected limbs were classified as five. Two grading systems were used in the evaluation of neural compromises. The incidence of RLS was 5.00% (32/639). There were 16 males (50%) and 16 females (50%). The median age at diagnosis was 55.4 years (range, 25-93 years). There are no correlation between the affected limbs of RLS and neural compromises on the lumbar spine. The RLS is a clearly common neurologic disorder of the limbs, usually the legs. The awareness of this syndrome can help reduce diagnostic error; thereby, avoiding the morbidity and expense associated with unnecessary studies or inappropriate treatments in RLS patients.
    Journal of Korean Neurosurgical Society 02/2014; 55(2):83-8. DOI:10.3340/jkns.2014.55.2.83 · 0.64 Impact Factor
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    • "In addition, in both the general population and in pregnant women, RLS is not associated with any changes in diurnal prolactin rhythms [51], even though serum prolactin levels in RLS is closely correlated with the periodic limb movement index, the number of period limb movements per hour of sleep [52]. Exogenous oestrogen has been shown to correlate with risk of RLS in peri-menopausal women [53], but not in younger women of childbearing age [54]. The rise of oestradiol levels and their decline after delivery have been shown to correlate well with worsening and subsequent improvement in gRLS and related periodic limb movement indices [51]. "
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    ABSTRACT: Insufficient sleep is common in the general population, and can result from environmental and psychosocial factors, medical and psychiatric disorders, and sleep disorders, such as insomnia, circadian rhythm disorders, sleep apnoea and restless legs. Women are particularly at risk for sleep disorders, and complaints of sleep disturbance are more prevalent among women than men across the life span. During the perinatal period, many common sleep disorders, such as obstructive sleep apnoea or restless legs may be exacerbated, or in the case of insomnia or narcolepsy, treatment options may change. In addition, the role of circadian rhythms in fertility and perinatal health is just beginning to be appreciated. In this chapter, we provide an overview of the current knowledge of the unique aspects of diagnosis and treatment of sleep disorders during the perinatal period.
    Best practice & research. Clinical obstetrics & gynaecology 10/2013; 28(1). DOI:10.1016/j.bpobgyn.2013.09.003 · 1.92 Impact Factor
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    ABSTRACT: Restless legs syndrome (RLS) is more common during pregnancy than in the general population, occurring at a 2-3 times higher prevalence. While iron, genetics, and central nervous system dopamine have been shown to play major roles in RLS unrelated to pregnancy, the etiology and treatment of RLS during pregnancy have not been adequately delineated. We describe a novel approach where a 23-year-old female was given intravenous iron prior to pregnancy, with complete remission of RLS symptoms until five months postpartum. Factors other than iron status that may have influenced the course of remission and relapse were oral contraceptive use, antidepressant use, and a strong family history of RLS. CITATION: Picchietti DL; Wang VC; Picchietti MA. Intravenous iron given prior to pregnancy for restless legs syndrome is associated with remission of symptoms. J Clin Sleep Med 2012;8(5):585-586.
    Journal of clinical sleep medicine: JCSM: official publication of the American Academy of Sleep Medicine 10/2012; 8(5):585-6. DOI:10.5664/jcsm.2168 · 3.05 Impact Factor
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