Article

Neural mechanisms of social risk for psychiatric disorders.

Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Nature Neuroscience (impact factor: 15.53). 04/2012; 15(5):663-8. DOI:10.1038/nn.3083 pp.663-8
Source: PubMed

ABSTRACT Mental health and social life are intimately inter-related, as demonstrated by the frequent social deficits of psychiatric patients and the increased rate of psychiatric disorders in people exposed to social environmental adversity. Here, we review emerging evidence that combines epidemiology, social psychology and neuroscience to bring neural mechanisms of social risk factors for mental illness into focus. In doing so, we discuss existing evidence on the effects of common genetic risk factors in social neural pathways and outline the need for integrative approaches to identify the converging mechanisms of social environmental and genetic risk in brain.

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Keywords

combines epidemiology
 
common genetic risk factors
 
frequent social deficits
 
genetic risk
 
increased rate
 
integrative approaches
 
Mental health
 
mental illness
 
social environmental
 
social environmental adversity
 
social life
 
social neural pathways
 
social psychology
 
social risk factors