Article

[Pre-washing catheter dramatically improves the post intrauterine insemination pregnancy rate].

Service d'histologie embryologie biologie de la reproduction, université Paris Descartes, 123, boulevard Port-Royal, 75014 Paris, France.
Gynécologie Obstétrique & Fertilité (impact factor: 0.52). 04/2012; 40(6):356-9. DOI:10.1016/j.gyobfe.2012.02.002 pp.356-9
Source: PubMed

ABSTRACT To analyze the effectiveness of pre-washing the intrauterine insemination catheters on IUI outcome.
Infertile couples (n=322) involved in a IUI program were included in the study. IUI indications were cervical factors, ovulation dysfunction, cryopreserved semen and unexplained infertility. Every other week for two years, IUI catheters were washed with culture medium prior to intrauterine sperm insemination.
Only the first IUI for each couple were analyzed. Washing the catheter, prior to use, resulted in a 49.7% increase in clinical pregnancy rate (22.0% vs 14.7% P<0.05). This result is observed with fresh sperm (15.7% vs 11.1%) and frozen-thawed sperm as well (31.1% vs 19.8%). The early pregnancy termination rate was similar in all groups.
Pre-washing the catheter before IUI should be recommended in Good Laboratory Practice Guidelines as it is already the case for embryo transfer catheters. This raises the problem of washing all single-use devices, in contact with gametes or embryos during IVF.

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Keywords

embryo transfer catheters
 
embryos
 
frozen-thawed sperm
 
gametes
 
Good Laboratory Practice Guidelines
 
Infertile couples
 
intrauterine insemination catheters
 
intrauterine sperm insemination
 
IUI catheters
 
IUI outcome
 
IVF
 
ovulation dysfunction
 
pre-washing
 
pregnancy termination rate
 
single-use devices
 
unexplained infertility
 

J-C Pont