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Malerich JP, Lam JS, Hart B, Fine RM, Klebansky B, Tanga MJ, D’Andrea, A. Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3. Bioorg Med Chem Lett. 2010; 20(24):7454-7457. DOI: 10.1016/j.bmcl.2010.10.026.

Bioorganic & Medicinal Chemistry Letters (Impact Factor: 2.34). 10/2010; 20(24):7454-7457.

ABSTRACT Tyrosine kinase 2 (TYK2) is required for signaling of interleukin-23 (IL-23), which plays a key role in rheumatoid arthritis. Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1–3.

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Sep 6, 2012