Digestive Disease Week 2011: Highlights of clinical and preclinical research on Barrett's esophagus and associated esophageal adenocarcinoma

Departments of Gastroenterology and Hepatology Internal Medicine Surgery, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Diseases of the Esophagus (Impact Factor: 1.78). 03/2012; 26(2). DOI: 10.1111/j.1442-2050.2012.01340.x
Source: PubMed


Clinicians and basic researchers worldwide convened at the annual Digestive Disease Week where the latest research in the field of gastroenterology and hepatology is presented. In this report, the highlights of the convention on the field of Barrett's esophagus (BE) and associated esophageal adenocarcinoma (EAC) are summarized. New clinical and preclinical developments in etiology, diagnosis, surveillance, and prevention and therapy of BE and EAC in respect to current knowledge are reflected. We also discuss the relevance and impact of these findings on the future of BE and EAC research.

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    • "The power of this kinome profiling was subsequently shown in various high profile studies, mainly focussing on cancerous disease. Two early studies, published in Cancer Research, used this platform to characterise the changes in the sequence of cellular events leading to adenocarcinoma of the oesophagus [63–66], whereas the other characterised signalling in colorectal cancer [67, 68], but this platform was also used for charting differences in the substrate specificity of related kinases, for example, to characterise the differences between c-Raf and Cot [69] or the phosphorylation target site of DMPK E and lats2 [70] and thus was the first academically truly successful peptide-array-based kinome profiling tool, used in a variety of species (e.g., Guinea pigs [71]). An important recently published study used this platform to characterise the changes in cellular kinome associated with differentiation during haematopoiesis [72], showing that even under unstimulated conditions important differences between cell stages exist, challenging the notion that cellular signalling is mainly reactive. "
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    ABSTRACT: The use of arrays in genomics has led to a fast and reliable way to screen the transcriptome of an organism. It can be automated and analysis tools have become available and hence the technique has become widely used within the past few years. Signal-transduction routes rely mainly on the phosphorylation status of already available proteins; therefore kinases are central players in signal-transduction routes. The array technology can now also be used for the analysis of the kinome. To enable array analysis, consensus peptides for kinases are spot on a solid support. After incubation with cell lysates and in the presence of radioactive ATP, radioactive peptides can be visualized and the kinases that are active in the cells can be determined. The present paper reviews comprehensively the different kinome array platforms available and results obtained hitherto using such platforms. It will appear that this technology does not disappoint its high expectations and is especially powerful because of its species independence. Nevertheless, improvements are still possible and I shall also sketch future possible directions.
    08/2012; 2012(8):306798. DOI:10.6064/2012/306798