R loops: lassoing DNA methylation at CpGi.
Department of Radiation Oncology and the Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30307, USA. Molecular cell
(Impact Factor: 14.02).
03/2012; 45(6):708-9. DOI: 10.1016/j.molcel.2012.03.014
In this issue of Molecular Cell, Ginno et al. (2012) describe unusual sequence features at promoter CpG islands that can lead to formation of persistent RNA-DNA hybrids (R loops), which are proposed to prevent genomic DNA methylation.
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