Negative Feedback Loops: Nutrient Starvation Employs a New tr(IKK) to Inhibit PI3K
ABSTRACT The PI3K pathway promotes insulin signaling to regulate metabolism and survival and is subject to multiple inhibitory feedback loops. In this issue of Molecular Cell,Comb et al. (2012) provide evidence indicating that the PI3K pathway is negatively regulated in a new way: by NFkB signaling during nutrient starvation.
SourceAvailable from: Mark T Mc AuleyJournal of Computer Science & Systems Biology 10/2013; 6(5):271. DOI:10.4172/jcsb.1000122