Randomized, Within-Patient, Clinical Trial Comparing Fluorine-Synthetic Fiber Socks with Standard Cotton Socks in Improving Plantar Pustulosis

Centro Studi GISED, Fondazione per la Ricerca Ospedale Maggiore , Bergamo , Italy.
Journal of Dermatological Treatment (Impact Factor: 1.76). 03/2012; 228(2). DOI: 10.3109/09546634.2012.681359
Source: PubMed

ABSTRACT Background: Rubbing the skin and trauma may influence the persistence of psoriasis over time. Objectives: To assess the impact of a new fabric made with a special fluorine-synthetic fiber in improving plantar psoriasis. Methods: A total of 20 patients with symmetrical lesions were randomized to receive on one side a sock made of fluorine-synthetic fiber and on the other side a sock made of cotton fabric for 4 weeks. The main outcome was the percentage reduction of lesional area. Results: In an intention-to-treat analysis, the median lesion reduction was 11.95% in fluorine-synthetic fiber arm and 11.89% in cotton arm (p = 0.776). Among secondary outcomes, patient global satisfaction showed a statistically significant median score of 32 toward fluorine-synthetic fiber arm (p = 0.011). Conclusion: In spite of our main negative results, it is important to continue investigating on the relation between textiles and skin disorders to improve patient well-being.

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