Randomized, Within-Patient, Clinical Trial Comparing Fluorine-Synthetic Fiber Socks with Standard Cotton Socks in Improving Plantar Pustulosis

Centro Studi GISED, Fondazione per la Ricerca Ospedale Maggiore , Bergamo , Italy.
Journal of Dermatological Treatment (Impact Factor: 1.67). 03/2012; 228(2). DOI: 10.3109/09546634.2012.681359
Source: PubMed


Rubbing the skin may influence the persistence of pustulosis over time. The aim of this study was to assess the impact of a new fabric made with fluorine-synthetic fiber in improving plantar pustulosis.

A total of 17 patients were randomized to receive on one side a sock made of fluorine-synthetic fiber and on the other a sock made of cotton fabric for 4 weeks. The main outcome was the percentage reduction of lesional area at week 4.

The median lesion reduction at week 4 was 42.6% in the fluorine-synthetic fiber arm and 2.7% in the cotton arm (p = 0.148). Among secondary outcomes, the overall reduction over time in the treated areas was significantly in favor of the fluorine-synthetic fiber arm (p = 0.045) as well as the perception of the disease by the patient (p = 0.025).

Despite the fact that the primary outcome was not reached, there was a tangible reduction in the extension of the treated areas and in the perception of the disease by the patient.

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