"Early and accurate diagnosis has great potential to reduce the costs related to care and living arrangements as it gives patients access to supportive therapies that can help them maintain their independence for longer and delay institutionalization (Paquerault, 2012; Prince et al., 2011). In addition, early diagnosis supports new research into understanding the disease process and developing new treatments (Paquerault, 2012; Prince et al., 2011). "
[Show abstract][Hide abstract] ABSTRACT: Algorithms for computer-aided diagnosis of dementia based on structural MRI have demonstrated high performance in the literature, but are difficult to compare as different data sets and methodology were used for evaluation. In addition, it is unclear how the algorithms would perform on previously unseen data, and thus, how they would perform in clinical practice when there is no real opportunity to adapt the algorithm to the data at hand. To address these comparability, generalizability and clinical applicability issues, we organized a grand challenge that aimed to objectively compare algorithms based on a clinically representative multi- center data set. Using clinical practice as starting point, the goal was to reproduce the clinical diagnosis. Therefore, we evaluated algorithms for multi-class classification of three diagnostic groups: patients with probable Alzheimer’s disease, patients with mild cognitive impairment and healthy controls. The diagnosis based on clinical criteria was used as reference standard, as it was the best available reference despite its known limitations. For evaluation, a previously unseen test set was used consisting of 354 T1-weighted MRI scans with the diagnoses blinded. Fifteen research teams participated with in total 29 algorithms. The algorithms were trained on a small training set (n=30) and optionally on data from other sources (e.g., the Alzheimer’s Disease Neuroimaging Initiative, the Australian Imaging Biomarkers and Lifestyle flagship study of aging). The best performing algorithm yielded an accuracy of 63.0% and an area under the receiver-operating-characteristic curve (AUC) of 78.8%. In general, the best performances were achieved using feature extraction based on voxel-based morphometry or a combination of features that included volume, cortical thickness, shape and intensity. The challenge is open for new submissions via the web-based framework: http://caddementia.grand-challenge.org.
"The growing prevalence of dementia is an increasing health problem [Alzheimer's Association, 2011]. Early and accurate diagnosis is beneficial for patient care, aiding the planning of care and living arrangements, and preserving function and independence for as long as possible [Paquerault, 2012; Prince et al., 2011]. In addition, an early and accurate diagnosis increases research opportunities into understanding the disease process and into the development of treatments. "
Human Brain Mapping 09/2014; 35(9). DOI:10.1002/hbm.22522 · 6.92 Impact Factor
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