Article

A diet based on multiple functional concepts improves cardiometabolic risk parameters in healthy subjects

Antidiabetic Food Centre, Lund University, P,O, Box 121, SE-221 00 Lund, Sweden. .
Nutrition & Metabolism (Impact Factor: 3.36). 04/2012; 9:29. DOI: 10.1186/1743-7075-9-29
Source: PubMed

ABSTRACT Different foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations. The objective of this study was to assess, in healthy overweight individuals, the impact of a diet combining multiple functional concepts on risk markers associated with cardiometabolic diseases (CMD).
Fourty-four healthy women and men (50-73 y.o, BMI 25-33, fasting glycemia ≤ 6.1 mmol/L) participated in a randomized crossover intervention comparing a multifunctional (active) diet (AD) with a control diet (CD) devoid of the "active" components. Each diet was consumed during 4 wk with a 4 wk washout period. AD included the following functional concepts: low glycemic impact meals, antioxidant-rich foods, oily fish as source of long-chain omega-3 fatty acids, viscous dietary fibers, soybean and whole barley kernel products, almonds, stanols and a probiotic strain (Lactobacillus plantarum Heal19/DSM15313).
Although the aim was to improve metabolic markers without promoting body weight loss, minor weight reductions were observed with both diets (0.9-1.8 ± 0.2%; P < 0.05). CD did not modify the metabolic variables measured. AD promoted significant changes in total serum cholesterol (-26 ± 1% vs baseline; P < 0.0001), LDL-cholesterol (-34 ± 1%; P < 0.0001), triglycerides (-19 ± 3%; P = 0.0056), LDL/HDL (-27 ± 2%; P < 0.0001), apoB/apoA1 (-10 ± 2%; P < 0.0001), HbA1c (-2 ± 0.4%; P = 0.0013), hs-CRP (-29 ± 9%; P = 0.0497) and systolic blood pressure (-8 ± 1%¸ P = 0.0123). The differences remained significant after adjustment for weight change. After AD, the Framingham cardiovascular risk estimate was 30 ± 4% (P < 0.0001) lower and the Reynolds cardiovascular risk score, which considers CRP values, decreased by 35 ± 3% (P < 0.0001).
The improved biomarker levels recorded in healthy individuals following the multifunctional regime suggest preventive potential of this dietary approach against CMD.

0 Followers
 · 
168 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Different starchy foods are frequently consumed in the Mexican diet. Some of them were developed by Pre-Columbian Mesoamerican civilizations. Until today, common beans (Phaseolus vulgaris), tortillas made with maize (Zea mays) and related maize-based products are some of the main staple foods. Additionally, wheat-based foods are also important starch sources, incorporated in different dishes. This review deals with the in vitro digestibility of the starch fraction in foods commonly consumed in Mexico, paying attention to the addition of unconventional, natural raw materials, such as flour and starch from unripe banana, mango dietary fibre and common legumes. These ingredients enhance potential health-beneficial properties of the diet in cases of non-communicable diseases, particularly those related to obesity and glycaemic homeostasis. Since Mexico is among the countries with greatest indices of overweight and obesity, this paper reviews the in vitro starch availability features, including predicted GI, of various Mexican foods. Attention is also paid to the effect of cold storage conditions on starch digestibility. As an example, starch digestibility in blue maize tortillas (58%) is lower than in white tortillas (70–89%) and a maize tortilla/boiled bean composite dish ranks as a food with low predicted GI (pGI = 51).
    Starch - Starke 01/2014; 66(1-2). DOI:10.1002/star.201200206 · 1.40 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The metabolic syndrome (MetS), characterized by obesity, hyperlipidemia, hypertension, and insulin resistance, is a growing epidemic worldwide, requiring new prevention strategies and therapeutics. The concept of prebiotics refers to selective stimulation of growth and/or activity(ies) of one or a limited number of microbial genus(era)/species in the gut microbiota that confer(s) health benefits to the host. Sequencing the gut microbiome and performing metagenomics has provided new knowledge of the significance of the composition and activity of the gut microbiota in metabolic disease. As knowledge of how a healthy gut microbiota is composed and which bacterial metabolites are beneficial increases, tailor-made dietary interventions using prebiotic fibers could be developed for individuals with MetS. In this review, we describe how dietary fibers alter short-chain fatty acid (SCFA) profiles and the intrinsic and extrinsic effects of prebiotics on host metabolism. We focus on several key aspects in prebiotic research in relation to MetS and provide mechanistic data that support the use of prebiotic fibers in order to alter the gut microbiota composition and SCFA profiles. Further studies in the field should provide reliable mechanistic and clinical evidence for how prebiotics can be used to alleviate MetS and its complications. Additionally, it will be important to clarify the effect of individual differences in the gut microbiome on responsiveness to prebiotic interventions.
    Nutrition 10/2013; 30(5). DOI:10.1016/j.nut.2013.08.013 · 3.05 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Purpose We compared the effects of a eucaloric moderate-fat diet (18 % protein, 36 % fat, and 46 % carbohydrate), a eucaloric low-fat high-carbohydrate diet (18 % protein, 18 % fat, and 64 % carbohydrate), and a low-calorie (33 % reduced) low-fat high-carbohydrate diet on biomarkers of systemic inflammation. Methods We randomly assigned 102 participants (age 21–76 years and BMI 19.2–35.5 kg/m2) to the three different diets for 6 weeks in a parallel design intervention trial. All foods were provided. Ninety-three participants completed all study procedures; 92 were included in the analyses. Endpoints included plasma C-reactive protein (CRP), interleukin-6 (IL-6), soluble tumor necrosis factor receptors I and II (sTNFRI and II), and adiponectin. Results In the unadjusted primary analyses, none of the endpoints were differentially affected by the dietary interventions despite the significantly greater reductions in body weight and fat mass in participants consuming the low-calorie low-fat diet compared to the eucaloric diets (p p = 0.051). Adjusted for weight change, adiponectin was reduced in the groups consuming the low-fat diets relative to the moderate-fat diet (p = 0.008). No effect of the intervention diets or weight loss on CRP, IL-6, or sTNFRI and II was seen in these secondary analyses. Conclusions In relatively healthy adults, moderate weight loss had minimal effects on systemic inflammation, and raised plasma adiponectin only modestly. A lower dietary fat and higher carbohydrate content had little impact on measures of systemic inflammation, but reduced adiponectin concentrations compared to a moderate-fat diet. The latter may be of concern given the consistent and strong inverse association of plasma adiponectin with many chronic diseases.
    European Journal of Nutrition 02/2015; DOI:10.1007/s00394-015-0841-1 · 3.84 Impact Factor

Full-text (3 Sources)

Download
48 Downloads
Available from
May 29, 2014