Article

Involvement of microRNA-93, a new regulator of PTEN/Akt signaling pathway, in regulation of chemotherapeutic drug cisplatin chemosensitivity in ovarian cancer cells.

Department of Gynecology Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
FEBS letters (impact factor: 3.54). 03/2012; 586(9):1279-86. DOI:10.1016/j.febslet.2012.03.006 pp.1279-86
Source: PubMed

ABSTRACT The mechanisms underlying ovarian cancer cell resistance to cisplatin (CDDP) are not fully understood. MicroRNAs (miRNAs) play important roles in tumorigenesis and drug resistance. In this paper, we utilized microRNA array and real-time PCR to show that miR-93 is significantly up-regulated in cisplatin-resistant ovarian cancer cells. In vitro assays show that over-expression and knock-down of miR-93 regulate apoptotic activity, and thereby cisplatin chemosensitivity, in ovarian cells. Furthermore, we found that miR-93 can directly target PTEN, and participates in the regulation of the AKT signaling pathway. MiR-93 inversely correlates with PTEN expression in CDDP-resistant and sensitive human ovarian cancer tissues. These results may have implications for therapeutic strategies aiming to overcome ovarian cancer cell resistance to cisplatin.

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Keywords

AKT signaling pathway
 
cisplatin
 
cisplatin chemosensitivity
 
cisplatin-resistant ovarian cancer cells
 
knock-down
 
MicroRNAs
 
miRNAs
 
ovarian cancer cell resistance
 
ovarian cells
 
over-expression
 
PTEN expression
 
sensitive human ovarian cancer tissues
 
therapeutic strategies
 
tumorigenesis
 

Xin Fu