Article

Macrophage migration inhibitory factor in protozoan infections.

Laboratório de Inflamação e Imunidade, Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, 21941-902, Rio de Janeiro, RJ, Brazil.
Journal of Parasitology Research 01/2012; 2012:413052. DOI: 10.1155/2012/413052
Source: PubMed

ABSTRACT Macrophage migration inhibitory factor (MIF) is a cytokine that plays a central role in immune and inflammatory responses. In the present paper, we discussed the participation of MIF in the immune response to protozoan parasite infections. As a general trend, MIF participates in the control of parasite burden at the expense of promoting tissue damage due to increased inflammation.

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May 20, 2014