Nocardia cyriacigeorgica Infections Attributable to Unlicensed Cosmetic Procedures-An Emerging Public Health Problem?
Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.Clinical Infectious Diseases (Impact Factor: 8.89). 04/2012; 55(2):251-3. DOI: 10.1093/cid/cis341
We describe an outbreak of Nocardia cyriacigeorgica soft-tissue infections attributable to unlicensed cosmetic injections and the first report using multilocus sequence typing sequence data for determining Nocardia strain relatedness in an outbreak. All 8 cases identified had a common source exposure and required hospitalization, surgical debridement, and prolonged antimicrobial therapy.
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ABSTRACT: Although exact statistics are lacking, body modifications for cosmetic purposes are performed in many countries. The commonest forms include tattooing, body piercing, and breast and facial augmentation using implants or injectable fillers. Liposuction and, to a lesser extent, mesotherapy are also practiced in many countries. Infective complications of these procedures include local infections, transmission of bloodborne pathogens (viral hepatitis and human immunodeficiency virus), and distant infections such as infective endocarditis. Presence of foreign bodies, long healing time of piercing wounds, and poor compliance with infection control practices of some practitioners all predispose the recipients to infections. Apart from the endogenous microbial flora of the skin and mucosae, atypical mycobacteria, especially the rapid growers, have emerged as some of the most important pathogens in such settings. Outbreaks of infection are commonly reported. We hereby review the current knowledge of the topic with specific focus on infections associated with tattooing, body piercing, breast augmentation, mesotherapy, liposuction, and tissue filler injections. Greater awareness among consumers and health-care professionals, as well as more stringent regulations by the health authorities, is essential to minimize the health risks arising from these procedures.Journal of the Formosan Medical Association 12/2012; 111(12):667-81. DOI:10.1016/j.jfma.2012.10.016 · 1.97 Impact Factor
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ABSTRACT: Objective: An attempt has been made to evaluate the optimal cultural conditions for obtaining high yields of bioactive metabolites. Methods: A strain of actinobacteria was isolated from the soil sample of Kaziranga National Park of Assam. Strain was identified on the basis of biochemical test as well as 16SrDNA sequence. The strain was tested for antibacterial activity using agar well diffusion method and to enhance its growth and metabolite production, the strain was cultured at different carbon and nitrogen sources and at different pH, salinity and temperature. Results: The strain was identified as Nocardia cyriacigeorgica. The secondary metabolites exhibited excellent antimicrobial activity against dreaded human pathogenic bacteria Staphylococcus aureus (MTCC 96), Bacillus subtilis (MTCC 441), Escherichia coli (MTCC 739) and Pseudomonas aeruginosa (MTCC 2453). The strain utilized glucose as good carbon source for growth and starch for metabolite production. Soybean meal and beef extract were the nitrogen sources for the elaboration of both growth and bioactive metabolites. The optimum temperature, salinity and pH for growth and bioactive metabolite production of the strain were recorded as 28±2 o C, 1.5% and 7.5 respectively. Conclusion: As our results showed the potency of N. cyriacigeorgica as an antibacterial agent under these optimal conditions, so further study can be carried out in this regard. This is the first report of production of antibacterial compound from this emerging pathogenic strain N. cyriacigeorgica.International Journal of Pharmacy and Pharmaceutical Sciences 01/2015; 7(3):258-262. · 1.59 Impact Factor
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