Gut-central nervous system axis is a target for nutritional therapies

Department of Internal Medicine, State University of Campinas, Campinas, Brazil.
Nutrition Journal (Impact Factor: 2.6). 04/2012; 11(1):22. DOI: 10.1186/1475-2891-11-22
Source: PubMed

ABSTRACT Historically, in the 1950s, the chemist Linus Pauling established a relationship between decreased longevity and obesity. At this time, with the advent of studies involving the mechanisms that modulate appetite control, some researchers observed that the hypothalamus is the "appetite centre" and that peripheral tissues have important roles in the modulation of gut inflammatory processes and levels of hormones that control food intake. Likewise, the advances of physiological and molecular mechanisms for patients with obesity, type 2 diabetes mellitus, inflammatory bowel diseases, bariatric surgery and anorexia-associated diseases has been greatly appreciated by nutritionists. Therefore, this review highlights the relationship between the gut-central nervous system axis and targets for nutritional therapies.

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Available from: Ronaldo Vagner Thomatieli Dos Santos, Sep 29, 2015
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    • "Moreover, many currently available psycho active drugs possess obesogenic potentials, and obesity is a major risk factor of insulin resistance and type 2 diabetes (Faulkner et al., 2009; Pan et al., 2012). It is now well recognized that diabetes and psychiatric disorders share a bidirectional association (Balhara, 2011), and that the gut-central nervous system could as well be the target for nutritional therapies (Pimentel et al., 2012). The crucial role of gut microbiota in the etiology, pathogenesis and progression of diabetes and associated comorbidities is now becoming increasingly apparent (Sekirov et al., 2010) and bacteriostatic activities of numerous phytochemical consumed with food and herbal remedies are well known. "
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    • "In normal circumstances, only small amounts of endotoxin cross from the intestinal lumen into systemic circulation, and the absorbed endotoxin is rapidly removed by monocytes, particularly resident Kupffer cells within the liver. Emerging evidence has indicated that chronic elevation of serum endotoxin levels may play a role in insulin-resistant states and obesity [4,5,10]. "
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