Article

Gut-central nervous system axis is a target for nutritional therapies

Department of Internal Medicine, State University of Campinas, Campinas, Brazil.
Nutrition Journal (Impact Factor: 2.64). 04/2012; 11:22. DOI: 10.1186/1475-2891-11-22
Source: PubMed

ABSTRACT Historically, in the 1950s, the chemist Linus Pauling established a relationship between decreased longevity and obesity. At this time, with the advent of studies involving the mechanisms that modulate appetite control, some researchers observed that the hypothalamus is the "appetite centre" and that peripheral tissues have important roles in the modulation of gut inflammatory processes and levels of hormones that control food intake. Likewise, the advances of physiological and molecular mechanisms for patients with obesity, type 2 diabetes mellitus, inflammatory bowel diseases, bariatric surgery and anorexia-associated diseases has been greatly appreciated by nutritionists. Therefore, this review highlights the relationship between the gut-central nervous system axis and targets for nutritional therapies.

Download full-text

Full-text

Available from: Ronaldo Vagner Thomatieli Dos Santos, Aug 11, 2015
0 Followers
 · 
212 Views
  • Source
    • "The human microbiome is a topic of considerable interest to researchers and health professionals. The gut is now known to be an important metabolic organ containing a diversity of bacterial species that influence the maintenance of health or development of diseases [Ley et al., 2006a; Pimentel et al., 2012], e.g., obesity, type 2 diabetes (T2D), hepatic steatosis, and hypertension [Caricilli et al., 2011; Kau et al., 2011; Henao-Mejia et al., 2012; Pluznick et al., 2013]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Preclinical ResearchThe gut microbiota is being increasingly appreciated by both clinical and research professionals as the human ancestral genome has undergone modification by the microbes that colonize the human body. The gut is now known to be a key metabolic organ that contains some 15 000 bacterial species that influence health and chronic diseases, the latter including obesity, type 2 diabetes, hepatic steatosis, and hypertension. Based on the potentially beneficial effects of nutrients, this review discusses how obesity disturbs the gut microbiota. Additionally, the main dietary nutrients known to modulate the intestine microbiome were highlighted.
    Drug Development Research 09/2013; 74(6). DOI:10.1002/ddr.21092 · 0.73 Impact Factor
  • Source
    • "Moreover, many currently available psycho active drugs possess obesogenic potentials, and obesity is a major risk factor of insulin resistance and type 2 diabetes (Faulkner et al., 2009; Pan et al., 2012). It is now well recognized that diabetes and psychiatric disorders share a bidirectional association (Balhara, 2011), and that the gut-central nervous system could as well be the target for nutritional therapies (Pimentel et al., 2012). The crucial role of gut microbiota in the etiology, pathogenesis and progression of diabetes and associated comorbidities is now becoming increasingly apparent (Sekirov et al., 2010) and bacteriostatic activities of numerous phytochemical consumed with food and herbal remedies are well known. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Brassica juncea is a polyphenols enriched edible plant, with diverse medicinal uses of different parts of which have been mentioned in the Ayurveda. The effects of 10 daily oral doses (100, 200, and 400 mg/kg/day) of a methanolic Brassica juncea leaf extract in rat models of anxiety using nondiabetic and alloxan-diabetic rats were quantified. In all the three behavioural tests used, i.e. elevated plus maze, open field, and social interaction tests, anxiolytic-like activity of the extract was observed in the diabetic animals only. Quantitatively, the efficacy of the highest tested dose of the extract in these tests was always less than those observed after its lower ones. These observations provide further experimental evidences for the conviction that Brassica vegetables could as well be useful for combating diabetes associated mental health problems.
    02/2013; 3:7.1-7.7. DOI:10.5667/tang.2012.0042
  • [Show abstract] [Hide abstract]
    ABSTRACT: Le cerveau, et plus particulièrement l’hypothalamus, est le centre intégrateur de nombreux signaux d’origines diverses impliqués dans le contrôle de la satiété et du métabolisme énergétique. Par l’intermédiaire des systèmes endocrinien et/ou nerveux, les tissus périphériques (tube digestif, tissu adipeux parmi les principaux) peuvent alors envoyer des messages à l’hypothalamus, qui en retour modulera la prise alimentaire et l’utilisation périphérique du glucose. Ainsi, la genèse d’un message périphérique aberrant et/ou l’arrivée d’une information erronée dans l’hypothalamus peuvent participer à l’apparition des maladies métaboliques (obésité, diabète de type 2). En plus des troubles périphériques liés à ces pathologies, il devient d’une importance majeure de traiter ces « troubles hypothalamiques » en agissant, dans la mesure du possible, directement sur des cibles hypothalamiques ou au contraire en ciblant des acteurs moléculaires, cellulaires et tissulaires périphériques connus pour communiquer avec l’hypothalamus. Dès lors, le traitement des maladies métaboliques passerait par une vision globale de l’organisme via la communication inter-organes et le système nerveux central comme centre intégrateur.
    Obésité 06/2013; 8(2). DOI:10.1007/s11690-013-0364-y
Show more