Article

Human papillomavirus (HPV) infection and genotype frequency in the oral mucosa of newborns in Milan, Italy.

Department of Public Health-Microbiology-Virology, University of Milan, Milan, Italy.
Clinical Microbiology and Infection (impact factor: 4.54). 03/2012; 18(6):E197-9. DOI:10.1111/j.1469-0691.2012.03839.x pp.E197-9
Source: PubMed

ABSTRACT Human papillomavirus (HPV) causes cutaneous and mucosal infections in both adults and children. In order to evaluate HPV prevalence and the spectrum of genotypes in the oral cavity of paediatric subjects, a retrospective study was carried out on oral-pharyngeal swabs collected from 177 newborns aged 0-6 months. HPV-DNA was detected by a nested-PCR; the viral typing was made through DNA sequencing. HPV infection was identified in 25 subjects (14.1%) and the sequence analysis showed eight distinct genotypes. These data confirm HPV detection in newborn oral mucosa. Further investigations are needed to clarify the methods of HPV acquisition.

0 0
 · 
0 Bookmarks
 · 
36 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

children
 
clarify
 
DNA sequencing
 
HPV infection
 
HPV-DNA
 
Human papillomavirus
 
mucosal infections
 
newborn oral mucosa
 
oral cavity
 
oral-pharyngeal swabs
 
paediatric subjects
 
retrospective study
 
sequence analysis
 

M Martinelli