DNA Origami Gatekeepers for Solid-State Nanopores

Walter Schottky Institute, Technische Universität München, Munich, Germany.
Angewandte Chemie International Edition (Impact Factor: 11.26). 05/2012; 51(20):4864-7. DOI: 10.1002/anie.201200688
Source: PubMed


DNA has it covered: DNA origami gatekeeper nanoplates convert nanopores in solid-state membranes into versatile devices for label-free macromolecular sensing applications. The custom apertures in the nanoplates can be chemically addressed for sequence-specific detection of DNA.

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Available from: Ulrich Rant, Oct 07, 2015
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    • "DNA nanotechnology is leading to various applications in structural biology (17), biophysics (18–20), biosensing (21–24) and therapeutic delivery (25–28), many of which entail the preparation of micrograms to milligrams of enriched high-quality DNA nanostructures. Traditional electrophoresis-based methods excel at separation resolution but often fall short in scalability. "
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