Increased serum angiopoietin-2 is associated with abdominal aortic aneurysm prevalence and cardiovascular mortality in older men.
ABSTRACT BACKGROUND: Angiopoietin-2 (Angpt2) has been implicated in the mediation and regulation of angiogenesis and inflammation which are believed to be critical mechanisms in the pathogenesis of both abdominal aortic aneurysm (AAA) and cardiovascular events. The aim of this study was to assess whether serum Angpt2 was associated with the prevalence of AAA and the occurrence of cardiovascular mortality in older men. METHODS: A cohort of 997 elderly men was recruited in 1996-99. Aortic ultrasound identified an AAA in 308 (31%). In 2001-04, blood was collected and serum Angpt2 later measured by immunoassay. The association of Angpt2 with AAA was assessed using multiple regression analysis. All men were followed by means of the Western Australia Data Linkage System until July 31st 2009. The association of Angpt2 with cardiovascular mortality was assessed using Cox proportional hazard analysis. RESULTS: Median serum Angpt2 was significantly higher (3.16ng/ml, inter-quartile range 2.51-4.54) in men with AAA compared with men without AAA (2.70ng/ml, inter-quartile range 2.03-3.72; p<0.001). After adjusting for cardiovascular risk factors, men with serum Angpt2 in the highest quartile (>3.95ng/ml) had a 2.57-fold (95% CI 1.66-3.97, p<0.001) increased odds of AAA and a 4.12-fold (95% CI 1.90-8.94, p<0.001) increased relative risk of cardiovascular mortality compared to men with serum Angpt2 in the lowest quartile (<2.13ng/ml). CONCLUSIONS: Serum Angpt2 is elevated in men with AAA and associated with an increased risk of cardiovascular mortality in older men.
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ABSTRACT: Background Angiopoietin 2 (Angpt2) impairs endothelial function by preventing Angiopoietin 1 from binding to their common endothelial-specific receptor Tie2. Here we examined whether circulating Angpt2 predicts outcome in kidney transplant recipients. Materials and Methods For this case-cohort study we selected 130 kidney transplant recipients who had died or returned to dialysis within the first two years of follow-up of our cohort study, as well as 130 age and gender-matched kidney transplant recipients without an event (controls) from a total of 993 kidney transplant recipients. The total of 260 selected patients were followed in median 4 years. Serum Angpt2 at baseline was measured using an in-house immuno-luminometric assay. ResultsMedian Angpt2 concentrations were significantly higher in patients who died (median [interquartile range – IQR] 3.6[2.8-5.9] ng/mL) as compared to patients who did not die during the study period (2.8[2.1-4.1] ng/mL; p<0.001). Ln (natural log) Angpt2 levels correlated positively with C-reactive protein levels (r=0.315, p<0.001), and the Charlson Comorbidity Index (r=0.188, p=0.002), and were inversely associated with eGFR (r=-0.301, p<0.001) hemoglobin (r=-0.269, p<0.001) and serum albumin concentrations (r=-0.382, p<0.001). On multivariate analyses baseline Angpt2 levels independently predicted all-cause mortality (multivariable adjusted hazard ratio associated with one natural log unit higher Angpt2 level: 1.70 (95% confidence interval: 1.10-2.61). Conclusions In our analysis circulating Angpt2 was an independent predictor of all-cause mortality in stable, prevalent kidney transplant recipients.This article is protected by copyright. All rights reserved.Transplant International 03/2014; · 3.16 Impact Factor