Aspirin and non-aspirin non-steroidal anti-inflammatory drug use and risk of lung cancer

Saw Swee Hock School of Public Health, National University of Singapore, MD3, 16 Medical Drive, Singapore 117597, Singapore. wei-yen
Lung cancer (Amsterdam, Netherlands) (Impact Factor: 3.96). 04/2012; 77(2):246-51. DOI: 10.1016/j.lungcan.2012.03.005
Source: PubMed


There is evidence that aspirin and non-aspirin non-steroidal anti-inflammatory drug (NSAID) have anti-carcinogenic properties, but their effect on lung cancer, in particular in never-smokers, is unclear. Information on past or current use of anti-inflammatory medication was obtained in 398 Chinese female primary lung cancer cases and 814 controls in a hospital-based study in Singapore. 65% of cases and 88% of controls were never-smokers. Controls were excluded if they had been admitted for conditions associated with aspirin or NSAID use (n=174). Regular aspirin use (twice a week or more, for a month or more) was associated with a reduced risk of lung cancer (adjusted odds ratio [OR] 0.50, 95% confidence intervals [95%CI] 0.31-0.81 in non-smokers; OR 0.38, 95%CI 0.16-0.93 in smokers). Regular use of non-aspirin NSAID, paracetamol, steroid creams and steroid pills was uncommon and no association with lung cancer was detected. Our results suggest that aspirin consumption may reduce lung cancer risk in Asian women and are consistent with current understanding of the role of cyclooxygenase in lung carcinogenesis.

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    • "In addition to its chemopreventive effects on colorectal cancers, aspirin has also been shown to have a beneficial role in reducing lung cancer incidence and mortality [8]. A pooled analysis conducted by the International Lung Cancer Consortium (ILCCO) suggests that aspirin use was significantly associated with reduced risk of lung cancer [16] regardless of the smoking status of the individual [17]. Of further interest, a study published within the last year suggests that aspirin use may also reduce metastasis of lung cancer cells to the regional lymph nodes, and thus has the potential to extend the lives of lung cancer patients [18]. "
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