Increasing materials' response to two-photon NIR light via self-immolative dendritic scaffolds.

Skaggs School Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, USA.
Chemical Communications (Impact Factor: 6.72). 04/2012; 48(73):9138-40. DOI: 10.1039/c2cc00072e
Source: PubMed

ABSTRACT Photoactivation using two photons of NIR allows non-invasive biological manipulation. We applied the principle of dendritic amplification to improve the materials' sensitivity to NIR light. Light induced uncaging or release of L-glutamic acid was 2.8 fold higher when incorporating 4-bromo-7-hydroxycoumarin (Bhc) with self-immolative dendrimers compared with Bhc directly conjugated to L-glutamic acid.

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