Article

Increasing materials' response to two-photon NIR light via self-immolative dendritic scaffolds.

Skaggs School Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, USA.
Chemical Communications (Impact Factor: 6.72). 04/2012; 48(73):9138-40. DOI: 10.1039/c2cc00072e
Source: PubMed

ABSTRACT Photoactivation using two photons of NIR allows non-invasive biological manipulation. We applied the principle of dendritic amplification to improve the materials' sensitivity to NIR light. Light induced uncaging or release of L-glutamic acid was 2.8 fold higher when incorporating 4-bromo-7-hydroxycoumarin (Bhc) with self-immolative dendrimers compared with Bhc directly conjugated to L-glutamic acid.

Download full-text

Full-text

Available from: Nadezda Fomina, Jul 02, 2015
0 Followers
 · 
107 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Photodegradable polyesters were synthesized with a photolabile monomer 2-nitrophenylethylene glycol and dioyl chlorides with different lengths. These polymers can be assembled to form polymeric particles with encapsulation of target substances. Light activation can degrade these particles and release payloads in both aqueous solutions and RAW 264.7 cells.
    International Journal of Molecular Sciences 12/2012; 13(12):16387-99. DOI:10.3390/ijms131216387 · 2.34 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: We synthesized a series of crosslinked photoresponsive polymeric particles with photolabile monomers and crosslinkers through miniemulsion polymerization. These particles are quite stable in dark, while light irradiation caused the breakage of particles and the efficient release of encapsulated contents up to 95 % based on Nile red fluorescence. Photoswitches of particle systems were confirmed by fluorescence spectroscopy, SEM and colorimetry. Particle uptake and triggered release in RAW264.7 cells were confirmed by fluorescein diacetate loaded particles. © 2013 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2013 The American Society of Photobiology.
    Photochemistry and Photobiology 01/2013; 89(3). DOI:10.1111/php.12038 · 2.68 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: This paper uses physical-organic studies on well-defined oligomers to establish design principles for creating aromatic poly(carbamates) that depolymerize from head-to-tail in low dielectric constant environments when exposed to specific applied signals. We show that either increasing electron density or decreasing the aromaticity of aromatic repeating units in poly(carbamates) increase the overall depolymerization rate. For example, a methoxybenzene-based repeating unit provides depolymerization rates that are 143× faster than oligomers that contain a benzene-based repeating unit. Furthermore, the rate of depolymerization in the methoxybenzene-based system is tolerant to low dielectric environments, whereas the benzene-based oligomers are not.
    The Journal of Organic Chemistry 02/2013; 78(7). DOI:10.1021/jo400105m · 4.64 Impact Factor