Increasing materials' response to two-photon NIR light via self-immolative dendritic scaffolds

Skaggs School Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, USA.
Chemical Communications (Impact Factor: 6.83). 04/2012; 48(73):9138-40. DOI: 10.1039/c2cc00072e
Source: PubMed


Photoactivation using two photons of NIR allows non-invasive biological manipulation. We applied the principle of dendritic amplification to improve the materials' sensitivity to NIR light. Light induced uncaging or release of L-glutamic acid was 2.8 fold higher when incorporating 4-bromo-7-hydroxycoumarin (Bhc) with self-immolative dendrimers compared with Bhc directly conjugated to L-glutamic acid.

Download full-text


Available from: Nadezda Fomina,
  • Source
    • "Two-photon absorption (2PA) is a typical nonlinear optical property that two photons are simultaneously absorbed to promote a molecule to the excited state by doubling the excitation energy. Introducing 2PA property to self-assembly system may find a variety of biomedical usages such as photodynamic therapy and drug delivery [36] [81]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: As a promising technique for preparing polymeric materials with novel structures and properties, self-assembly is gaining increasing attentions. The applications of self-assemblies raise the claim of full expression of inherent functions and adequate stimuli-responsive features. Light is an excellent media for the realization of inherent functions, in favor of the communication with external environments. The aggregates self-assembled from polymers with optical functions can bring multifarious optical properties and promising applications. In the assemblies, the emission and fluorescence properties of polymers are dependent on both the aggregation type of the polymers and the aggregation-induced effects including planarization and specific intermolecular interactions. The aggregation-induced optical properties are influenced by external stimuli including pH and temperature, which confer various applications, such as in the areas of bioimaging and optical sensor. When photo-responsive groups with photochromism, photo-crosslink or photo-degradation properties are incorporated into polymers, self-assemblies are able to change their shape and inner structure under light irradiation. Such light triggered property is suitable in application for controllable release of loaded species from assemblies. We also discuss the challenges and developing directions regarding the studies and applications of self-assemblies from polymers with optical properties.
    European Polymer Journal 04/2015; 65. DOI:10.1016/j.eurpolymj.2015.01.023 · 3.01 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Photodegradable polyesters were synthesized with a photolabile monomer 2-nitrophenylethylene glycol and dioyl chlorides with different lengths. These polymers can be assembled to form polymeric particles with encapsulation of target substances. Light activation can degrade these particles and release payloads in both aqueous solutions and RAW 264.7 cells.
    International Journal of Molecular Sciences 12/2012; 13(12):16387-99. DOI:10.3390/ijms131216387 · 2.86 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: We synthesized a series of crosslinked photoresponsive polymeric particles with photolabile monomers and crosslinkers through miniemulsion polymerization. These particles are quite stable in dark, while light irradiation caused the breakage of particles and the efficient release of encapsulated contents up to 95 % based on Nile red fluorescence. Photoswitches of particle systems were confirmed by fluorescence spectroscopy, SEM and colorimetry. Particle uptake and triggered release in RAW264.7 cells were confirmed by fluorescein diacetate loaded particles. © 2013 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2013 The American Society of Photobiology.
    Photochemistry and Photobiology 01/2013; 89(3). DOI:10.1111/php.12038 · 2.27 Impact Factor
Show more