Microsomal and peroxisomal fatty acid oxidation in streptozotocin diabetic rat liver

Department of Biochemistry, Faculty of Medicine, University of Chile, Santiago 7, Chile, [fax: 56-2-735-55-80]
General Pharmacology: The Vascular System 03/1997; DOI: 10.1016/S0306-3623(96)00231-5

ABSTRACT Microsomal lauric acid hydroxylation and fatty acid peroxisomal β-oxidation were studied in hepatic subcellulant preparations from streptozotocin-induced diabetic and diabetic insulin-treated rats. 1.2. The liver microsomes of the streptozotocin diabetic rats displayed a similar activity to hydroxylate lauric acid as the control microsomes.2.3. Diabetic insulin-treated rats showed lower (ω1) and ω-lauric acid hydroxylase activities than diabetic and control rats.3.4. Streptozotocin-induced diabetes and diabetic insulin-treated rats exhibited no significant changes on peroxisomal palmitoyl CoA β-oxidation compared to the control rats.4.5. Both microsomal and peroxisomal fatty acid oxidation responded in a similar way in this model of experimental diabetes.