Synthesis, characterization and properties of chitosan modified with poly(ethylene glycol)–polydimethylsiloxane amphiphilic block copolymers

Department of Chemistry, Mahidol University, Krung Thep, Bangkok, Thailand
Polymer (Impact Factor: 3.56). 11/2005; 46(23):9742-9752. DOI: 10.1016/j.polymer.2005.08.051


Synthesis of poly(ethylene glycol)-polydimethylsiloxane amphiphilic block copolymers is discussed herein. Siloxane prepolymer was first prepared via acid-catalyzed ring-opening polymerization of octamethylcyclotetrasiloxane (D4) to form polydimethylsiloxane (PDMS) prepolymers. It was subsequently functionalized with hydroxy functional groups at both terminals. The hydroxy-terminated PDMS can readily react with acid-terminated poly(ethylene glycol) (PEG diacid) to give PEG–PDMS block copolymers without using any solvent. The PEG diacid was prepared from hydroxy-terminated PEG through the ring-opening reaction of succinic anhydride. Their chemical structures and molecular weights were characterized using 1H NMR, FTIR and GPC, and thermal properties were determined by DSC. The PEG–PDMS copolymer was incorporated into chitosan in order that PDMS provided surface modification and PEG provided good water swelling properties to chitosan. Critical surface energy and swelling behavior of the modified chitosan as a function of the copolymer compositions and contents were investigated.

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Available from: Metha Rutnakornpituk, Oct 02, 2015
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    • "PDMS is of particular interest in this work owing to their unique properties, e.g. low toxicity, high oxygen permeability, good flexibility, good thermal and oxidative stability (Guo, Han, Wang, Xiao, & Dai, 2007; Rutnakornpituk, Ngamdee, & Phinyocheep, 2005b; Wang, Xu, & Chen, 2007). It is also widely used in medical applications due to its biocompatibility, good oxidative stability and high oxygen permeability (Akimoto, Aoyagi, Minoshima, & Nagase, 1997). "
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