Article

Differential co-localization of nicotinic acetylcholine receptor subunits with calcium-binding proteins in retinal ganglion cells

Department of Histology and Embryology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, São Paulo SP 05508-900, Brazil; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo SP 05508-900, Brazil; Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6074, USA; Department of Neurosciences, School of Medicine, University of California at San Diego, La Jolla, CA 92093-0608, USA
Brain Research (impact factor: 2.73). 12/1997; DOI:10.1016/S0006-8993(97)81715-5 pp.250-255

ABSTRACT Immunohistochemistry was used to examine the co-occurrence of nicotinic acetylcholine receptor subunits with calcium-binding proteins in ganglion cells of the chick retina. The α3 subunit was rarely observed in ganglion cells containing calbindin, calretinin, or parvalbumin. On the other hand, the α8 subunit was more often co-localized with all calcium-binding proteins studied. These results may be related to the high calcium permeability of nicotinic receptors that contain the α8 subunit.

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Keywords

calbindin
 
calcium permeability
 
calcium-binding proteins
 
chick retina
 
ganglion cells
 
Immunohistochemistry
 
nicotinic acetylcholine receptor subunits