Article

Nitric oxide synthase activities in human myocardium

Department of Cardiology, King's College Hospital , United Kingdom; Department of Medicine, King's College School of Medicine and Dentistry, London SE5, United Kingdon; Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, UK
The Lancet DOI:10.1016/0140-6736(93)92559-C

ABSTRACT Myocardial constitutive and inducible nitric oxide (NO) synthase activities were measured in right ventricular tissue from 17 patients with dilated cardiomyopathy (DCM). A significant activity of inducible enzyme was accompanied by a low activity of the constitutive NO synthase. Thus, the myocardium has the capacity to express both NO synthases. NO may have a physiological as well as a pathological role in the human myocardium. Lancet 1993; 341: 84-85.

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Keywords

17 patients
 
dilated cardiomyopathy
 
human myocardium
 
inducible enzyme
 
low activity
 
Myocardial constitutive
 
significant activity
 
synthases
 
ventricular tissue