Intracranial Rosai–Dorfman disease: Case report and literature review
ABSTRACT Rosai–Dorfman disease (RDD) is an idiopathic, non-neoplastic, lympho-histiocytic proliferative disorder characterized by sinus histiocytosis and massive lymphadenopathy. Intracranial RDD is mainly a disease characterized by dura-based masses and/or diffuse meningeal thickening and included a broad differential diagnosis radiologically. The authors report an unusual case of a 38-year-old male patient presenting with bilateral multiple intracranial dura-based nodules and diffuse meningeal thickening as well as intra-spinal canal involvement. The MR imaging and histo-pathological features of the disease are discussed. Histology with immunohistochemical analysis, in which it demonstrates emperipolesis (lymphophagocytosis) feature and that most of the histiocytes stained with strong positivity for S100 and CD68 proteins, is essential for a definitive diagnosis.
- Archives of pathology 02/1969; 87(1):63-70.
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ABSTRACT: Rosai-Dorfman disease (RDD) is an idiopathic histiocytic proliferation affecting the lymph nodes. Isolated intracranial RDD is rare and usually appears as a well-defined, dural-based lesion without lymphadenopathy. The clinical and radiological features of intracranial RDD are similar to meningioma. Histopathology and immunohistochemistry are essential for a definitive diagnosis. This is a report of a 43-year old male with isolated intracranial RDD, which manifested as a suprasellar meningioma. The clinical, radiological and pathological aspects of the disease are discussed within the context of a review of previously reported cases.The Journal of international medical research 10/2008; 36(5):1134-9. DOI:10.1177/147323000803600535 · 1.10 Impact Factor
- American Journal of Ophthalmology 03/2007; 143(3):544. DOI:10.1016/j.ajo.2007.01.010 · 4.02 Impact Factor