Article

Nasal instillation of gpMBP can exacerbate murine EAE: effect of mucosal priming is an age-dependent phenomenon

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095-1489, USA; Department of Immunology, George Washington University Medical Center, Washington, DC 20037-2336, USA; Department of Immunology and Microbiology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, MI 48201, USA; Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
Journal of Autoimmunity DOI:10.1016/j.jaut.2003.09.005

ABSTRACT Nasal installation or oral feeding of antigens can alter the subsequent immune response in animals and humans. Most mucosal treatments with antigens tend to down-regulate disease, inducing full tolerance or immune deviation; however, priming has also been reported. We evaluated the course of experimental autoimmune encephalomyelitis (EAE) in (SJL×B10.PL)F1 mice after nasal instillation of myelin basic protein. There was a tendency towards exacerbation of subsequent disease in animals if they were nasally exposed to gpMBP during the neonatal period (first week of life), compared to exposure during adulthood. Later, at 11 months of age, this tendency to exacerbate disappeared. Our results suggest that mucosal exposure during early life may regularly modulate the anti-self immune response upwards in individuals genetically predisposed to autoimmune diseases.

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Keywords

11 months
 
anti-self immune response
 
autoimmune diseases
 
down-regulate disease
 
experimental autoimmune encephalomyelitis
 
first week
 
gpMBP
 
humans
 
immune deviation
 
individuals genetically predisposed
 
inducing full tolerance
 
mucosal exposure
 
myelin basic protein
 
Nasal installation
 
nasal instillation
 
neonatal period
 
oral
 
subsequent immune response