Article

Influence of particle wall adhesion on particle electrification in mixers

Institute of Chemical and Engineering Sciences, 1, Pesek Road, Jurong Island, Singapore 627833, Singapore; Department of Chemical & Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore; Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore
International Journal of Pharmaceutics DOI:10.1016/j.ijpharm.2006.07.041 pp.22-34

ABSTRACT In this work, particle electrification in the Turbula and horizontally oscillating mixers were investigated for adipic acid, microcrystalline cellulose (MCC), and glycine particles. MCC and glycine particles acquired positive electrostatic charges, while adipic acid particles attained negative charges in both mixers. Adipic acid (of sieved size larger than 500 μm), MCC, and glycine particles were monotonically charged to saturated values, and had negligible wall adhesion. On the contrary, the adipic acid particles, both unsieved and sieved but of smaller sieved size fraction, exhibited very different charging kinetics in the horizontally oscillating mixer. These adipic acid particles firstly acquired charges up to a maximum value, and then the charges slowly reduced to a lower saturated value with increasing mixing time. Furthermore, these particles were found to adhere to the inner wall of the mixer, and the adhesion increased with mixing time. Surface specific charge densities for adipic acid particles were estimated based on particle size distribution, and were found to increase with particle mean diameters under the conditions investigated. The results obtained from the current work suggested that electrostatic force enhanced particle–wall adhesion, and the adhered particles can have a significant impact on particle electrification.

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Keywords

adhered particles
 
adipic acid particles
 
adipic acid particles attained negative charges
 
current work
 
electrostatic force
 
glycine particles
 
horizontally oscillating
 
horizontally oscillating mixers
 
maximum value
 
microcrystalline cellulose
 
negligible wall adhesion
 
particle electrification
 
particle size distribution
 
particle–wall adhesion
 
positive electrostatic charges
 
sieved size larger
 
significant impact
 
smaller sieved size fraction
 
Surface specific charge densities
 
unsieved
 

Kewu Zhu