Article

Recent advances in the search for new drugs for treatment of toxoplasmosis

Department of Immunology & Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Palo Alto, California, USA; Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California, USA
International Journal of Antimicrobial Agents (Impact Factor: 4.42). 02/1992; DOI:10.1016/0924-8579(92)90002-9

ABSTRACT Although the combination of pyrimethamine with a sulfonamide is still very effective for treatment of toxoplasmosis the use of these two drugs immunocompromised individuals, particularly AIDS patienst, often results in a remarkable incidence of adverse reactions. There is, therefore, an urgent need for alternative drugs and newer therapeutic regimens for treatment of human toxoplasmosis. In this review, the in vitro and in vivo activities of a number of new drugs and new therapeutic regimens that have shown promising results in vartious experimental models for toxoplasmosisared discussed.

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Fausto G. Araujo