Article

Microcystic adnexal carcinoma

Department of Dermatology, University of Michigan Medical Center; Department of Otorhinolaryngology, University of Michigan Medical Center; Department of Surgery (Division of Plastic Surgery), University of Michigan Medical Center; Department of Dermatology, Henry Ford Hospital
Journal of the American Academy of Dermatology (impact factor: 3.99). 12/1993; DOI:10.1016/0190-9622(93)70251-N pp.840-845

ABSTRACT Microcystic adnexal carcinoma is a rare cutaneous neoplasm characterized by invasive, relentless, and destructive local growth. The incidence of perineural invasion and tumor recurrence is high. We report two cases of microcystic adnexal carcinoma with typical clinical features. The use of formalin-fixed, paraffin-embedded horizontal Mohs sections is described in one case. We also review the current concepts and management of microcystic adnexal carcinoma.

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    Article: Microcystic adnexal carcinoma: collaborative series review and update.
    P M Friedman, R H Friedman, S B Jiang, K Nouri, R Amonette, P Robins
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    ABSTRACT: Microcystic adnexal carcinoma (MAC) is a malignant appendageal tumor first described in 1982. It can be clinically and histologically confused with other malignant and benign cutaneous neoplasms, leading to inadequate initial treatment. This neoplasm is locally aggressive and deeply infiltrating, characterized by high morbidity and frequent recurrence. Mohs micrographic surgery has been used to conserve tissue and improve the likelihood for cure. We report our experience using Mohs micrographic surgery for the treatment of MAC and compare with earlier reports in the literature. In addition, we review the epidemiology, clinical and histologic characteristics, and optimal treatment of this rare neoplasm. We also describe a 15-year-old white male patient with MAC on the scalp occurring only 7 years after radiation exposure. The medical records of 11 patients with MAC who were treated by Mohs micrographic surgery were reviewed at both departments, and follow-up data were obtained. In all patients treated with Mohs micrographic surgery, there were no recurrences after a mean follow-up of 5 years. Mohs technique enables the detection of clinically unrecognizable tumor spread and perineural invasion often encountered with MAC. Aggressive initial treatment by microscopically controlled excision appears to offer the greatest likelihood of cure for this neoplasm, while providing conservation of normal tissue. In addition, we describe the second youngest patient with MAC and readdress the issue of previous radiotherapy as an important predisposing factor.
    Journal of the American Academy of Dermatology 09/1999; 41(2 Pt 1):225-31. · 3.99 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

destructive local growth
 
invasive
 
Microcystic adnexal carcinoma
 
rare cutaneous neoplasm
 
relentless
 
tumor recurrence