Article

[Expression and significance of neurogenic differentiation protein in pancreatic carcinoma].

Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Zhonghua bing li xue za zhi Chinese journal of pathology 01/2012; 41(1):23-7. pp.23-7
Source: PubMed

ABSTRACT To investigate the expression and significance of neurogenic differentiation protein (NeuroD) in pancreatic carcinoma.
The expression of NeuroD, PCNA and p53 proteins in 127 specimens of pancreatic carcinoma was detected by tissue microarray and immunohistochemestry. The correlations were analyzed between NeuroD and PCNA, p53, neural invasion, sleeve-like lymphocytic infiltration around the nerve, pancreatitis adjacent to carcinoma, lymph node metastasis and age, gender, location of tumors, histological types and differentiation of pancreatic carcinomas.
The positive rates of NeuroD, PCNA and p53 expression were higher in pancreatic carcinoma than those in non-tumor pancreatic tissues [64.6% (82/127) vs 10.5% (8/76), 57.5% (73/127) vs 9.2% (7/76), 59.1% (75/127) vs 9.2% (7/76), P < 0.01]. NeuroD expression in pancreatic carcinoma was related to that of PCNA and p53 and neural invasion (P < 0.05). No significant correlation was found between NeuroD and age, gender, tumor location, histological types and differentiation, sleeve-like lymphocytic infiltration, pancreatitis adjacent to the carcinoma and lymph node metastasis in pancreatic carcinomas.
NeuroD overexpression in pancreatic carcinoma. The overexpression of NeuroD may contribute to the tumorogenesis and development of pancreatic carcinoma, and is closely correlated to the cancer cell proliferation, p53 signal pathway and neural invasion in pancreatic carcinoma.

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Keywords

127 specimens
 
cancer cell proliferation
 
histological types
 
lymph node metastasis
 
neural invasion
 
NeuroD overexpression
 
neurogenic differentiation protein
 
non-tumor pancreatic tissues [64.6%
 
overexpression
 
p53 expression
 
p53 proteins
 
pancreatic carcinoma
 
pancreatic carcinomas
 
pancreatitis adjacent
 
positive rates
 
sleeve-like lymphocytic infiltration
 
tissue microarray
 
tumor location
 
tumorogenesis
 
tumors